153355-70-5

Usage

Uses

Used in Pharmaceutical Industry:
Ginkgolide K is used as a therapeutic agent for its anti-inflammatory, antioxidant, and neuroprotective properties, making it suitable for the treatment of neurological disorders, cardiovascular diseases, and inflammatory conditions.
Used in Health Supplements:
Ginkgolide K is used as a dietary supplement to promote healthy blood circulation and improve cognitive function, contributing to overall human health and well-being.
Used in Drug Development:
Ginkgolide K is utilized as a key compound in the development of new drugs targeting various health conditions, owing to its diverse range of therapeutic effects and potential for synergistic interactions with other compounds.

Upstream product

• 130523-06-7 1-(tert-butyldiphenylsilyloxy)-3,10-dihydroxyginkgolid 
• 15291-77-7 ginkgolide B 
• 153355-69-2 1-(tert-butyldiphenylsilyloxy)-10-hydroxy-3,14-didehydroginkgolid 

Relevant academic research and scientific papers

A preparation method of Ginkgolide K

The invention discloses a method for preparing ginkgolide K. The method includes the following steps: 1, ginkgolide B is dissolved into organic solvents to obtain a solution; 2, fluorinating agents are added into the solution obtained in the step 1 for conducting a dehydration reaction, and the ginkgolide K is obtained through separation and purification. The method for preparing the ginkgolide K is easy to operate; meanwhile, the high yield and the high purity are achieved, and convenience is brought to industrialization large-scale production. (please see the specification for the formula).

Ginkgolide K derivative and its preparation and use

The invention discloses a bilobalide K derivative and a preparation method and application thereof according to the formula I. Since structural modification is performed on bilobalide K, the bilobalide K derivative with higher water solubility and higher activity can be obtained and applied to prevention and treatment of cardiovascular and cerebrovascular diseases. Meanwhile, the bilobalide K derivative preparation process is facilitated and is adaptive to industrial production. (img file = 'DDA0000748217710000011.TIF' wi = '595' he = '515' /).

A concise synthesis of ginkgolide M, a minor component of a terpene trilactone fraction from Ginkgo biloba roots

Ginkgolide M (GM), which is found only in the roots of the Ginkgo biloba tree and is an inhibitor of ligand-operated ion channels in the central nervous system, has been prepared in three steps from 10-benzylginkgolide C, an intermediate generated during the isolation and separation of ginkgolides from Ginkgo biloba leaf extract. The described synthetic sequence can be applied to access GM derivatives for biological studies.

Chemistry of the Ginkgolides, VI. - Preparation of 1,10-Dihydroxy- and 1,7,10-Trihydroxyginkgolide from 1,3,7,10-Tetrahydroxyginkgolide

1,3,7,10-Tetrahydroxyginkgolide ("ginkgolide C", 1) which can be isolated in large quantities from the terpene fraction of Ginkgo leaves, can be converted into 1-(tert-butyldiphenylsilyloxy)-3,7,10-trihydroxyginkgolide (2) in 95percent yield. 2 was conver