- Photophysical and electrochemical studies of highly fluorescent pyrazole and imidazole containing heterocycles
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Highly congested pyrazole and imidazole ring containing heterocycles were studied for their photophysical and electrochemical properties. TDDFT calculations of the molecules were carried out using B3LYP/G(d,p) level theory in DMF medium and the results we
- Maurya, Hardesh K.,Kumar, Ch. Pavan,Chandrasekharam,Gupta, Atul
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p. 686 - 696
(2016/09/28)
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- A carbanion induced synthesis of highly congested pyrazole and imidazole containing heterocycles
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An efficient approach to the synthesis of highly congested di, penta and hexacyclic pyrazoles as well as imidazole fragment containing novel heterocyclic molecule has been developed through a carbanion induced transformation of suitably functionalized 2H-
- Maurya, Hardesh K.,Gupta, Atul
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supporting information
p. 1715 - 1719
(2014/03/21)
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- Studies on substituted benzo[h]quinazolines, benzo[g]indazoles, pyrazoles, 2,6-diarylpyridines as anti-tubercular agents
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Various substituted 5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine, 1-(3-(4-alkoxyphenyl)-7-methoxy-3,3a,4,5-tetrahydro-2H benzo[g]indazol-2-yl) ethanone, pyrazole and 2,6-diarylpyridine derivatives have been synthesized in good yields by an efficient me
- Maurya, Hardesh K.,Verma, Ruby,Alam, Saba,Pandey, Shweta,Pathak, Vinay,Sharma, Sandeep,Srivastava, Kishore K.,Negi, Arvind S.,Gupta, Atul
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p. 5844 - 5849
(2013/10/22)
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- Synthesis of novel heterocyclic compounds: Routes to pyrazolyl 1,2,3-triazoles and their biological activity evaluation
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A series of 5-aryl-3-cyanomethylpyrazoles have been synthesized by refluxing 6-aryl-3-cyano-4-methylthio-2H-pyran2-ones with hydrazine. The active methylene moiety of these pyrazoles has further been exploited to build 1,4-disubstituted 5-amino-1,2,3-tria
- Kumar, Ajay,Husain, Mofazzal,Prasad, Ashok K.,Singh, Ishwar,Vats, Archana,Sharma, Nawal K.,Sharma, Sunil K.,Gupta, Rajinder K.,Olsend, Carl E.,Bracke, Marc E.,Gross, Richard A.,Parmar, Virinder S.
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p. 1950 - 1957
(2007/10/03)
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- Synthesis of E- and Z-Pyrazolylacrylonitriles and their evaluation as novel antioxidants
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A facile synthesis of (Z)- and (E)-2-(5-arylpyrazol-3-yl)-3-(pyrrol-2-yl)acrylonitriles and (Z)-2-(1,3-diarylpyrazol-5-yl)-3-(pyrrol-2-yl)acrylonitriles, and isomerisation of (Z)-2-(5-arylpyrazolyl)acrylonitriles to (E)-2-(5-arylpyrazolyl)acrylonitriles under basic conditions have been reported. (Z)-2-(1,3-Diarylpyrazolyl)acrylonitriles did not undergo isomerisation under the similar conditions. New compounds were identified on the basis of their spectral data (1H-, 13C-, 1H-1H COSY, NOESY, NOE, HMQC NMR, IR, UV and EI mass). The structures of one acrylonitrile and five of their precursor 6-arylpyran-2-ones and cyanomethylpyrazoles were confirmed by X-ray crystallographic studies. Effects of pyrazolylacrylonitriles and their precursors on rat liver-microsomal lipid peroxidation were evaluated in vitro with a view to establish structure-activity relationship and to identify a lead compound. Copyright (C) 1999 Elsevier Science Ltd.
- Parmar, Virinder S.,Kumar, Ajay,Prasad, Ashok K.,Singh, Sanjay K.,Kumar, Naresh,Mukherjee, Shubhasish,Raj, Hanumantharao G.,Goel, Sanjay,Errington, William,Puar, Mohindar S.
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p. 1425 - 1436
(2007/10/03)
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- Synthetic and mass spectral fragmentation studies on trisubstituted 2H-pyran-2-ones and comparative EIMS behaviour of biologically active 3,5-disubstituted pyrazoles and isoxazoles
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Eight 3-cyano-4-thiomethyl-6-aryl-2H-pyran-2-ones 1-8 and three 3-cyano-4-(N,N-dimethy)amino-6-aryl-2H-pyran-2-ones 9-11 have been synthesised and their detailed mass fragmentation pattern alongwith the X-ray crystal structure of a novel pyrone 5 have been studied. In addition, a comparative EIMS behaviour of 3,5-disubstituted pyrazoles 16-23 and isoxazoles 12-15 is reported. The pyrazole derivative 23 has been found to possess strong anti-invasive activity against human breast carcinoma cells.
- Parmar, Virinder S.,Jain, Subhash C.,Jha, Amitabh,Kumar, Naresh,Kumar, Ajay,Vats, Archana,Jha, Hriday N.,Mukherjee, Shubhasish,Singh, Sanjay K.,Jennings, Keith R.,Summerfield, Scott G.,Errington, William,Olsen, Carl E.
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p. 872 - 879
(2007/10/03)
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- Ring transformation reaction: Part II - Reaction specificity of hydrazines towards 6-aryl-4-(methylthio)-2-oxo-2H-pyran-3-carbonitriles and corresponding 3-ethyl carboxylate
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Reaction specificity of hydrazine hydrate, cyclohexyl- and phenyl-hydrazines towards 6- or 5,6-disubstituted-4-(methylthio)-2-oxo-2H-pyran-3-carbonitriles and the corresponding 3-ethyl carboxylate (1,8) has been studied.
- Ram, Vishnu Ji,Haque, Navedul,Singh, Sanjay Kumar,Hussaini, Falak Anwer,Shoeb, Aboo
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p. 924 - 928
(2007/10/02)
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