1534350-44-1

Usage

Molecular Structure

1-methyl-4-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-1H-pyrazole consists of a pyrazole ring, a methyl group, a phenyl group, and a boron-containing dioxaborolane group.

Pyrazole Ring

A five-membered heterocyclic compound with one nitrogen atom and one carbon atom in the ring.

Methyl Group (CH3)

A small alkyl group consisting of one carbon atom bonded to three hydrogen atoms, attached to the pyrazole ring.

Phenyl Group (C6H5)

A six-membered carbon ring with alternating single and double bonds, attached to the pyrazole ring.

Boron-Containing Dioxaborolane Group

A boron-containing group with a [1,3,2]dioxaborolane structure (a three-membered ring with two oxygen atoms and one boron atom) attached to a phenyl group.

Unique Reactivity

The compound's complex structure and the presence of different functional groups contribute to its unique chemical reactivity.

Potential Applications

Due to its unique structure and reactivity, 1-methyl-4-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-1H-pyrazole has potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science.

Further Investigation

The specific properties and potential uses of 1-methyl-4-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-1H-pyrazole would need to be explored through laboratory research and testing to better understand its behavior and possible applications.

Upstream product

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• 761446-44-0 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 

Relevant academic research and scientific papers

Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core

The furo [3,2-b]pyridine motif represents a relatively underexplored central pharmacophore in the area of kinase inhibitors. Herein, we report flexible synthesis of 3,5-disubstituted furo [3,2-b]pyridines that relies on chemoselective couplings of newly prepared 5-chloro-3-iodofuro [3,2-b]pyridine. This methodology allowed efficient second-generation synthesis of the state-of-the-art chemical biology probe for CLK1/2/4 MU1210, and identification of the highly selective inhibitors of HIPKs MU135 and MU1787 which are presented and characterized in this study, including the X-ray crystal structure of MU135 in HIPK2. chemical biology probe

Design, synthesis and biological evaluation of 1H-indazole derivatives as novel ASK1 inhibitors

Apoptosis signal-regulating kinase 1 (ASK1, MAP3K5), a member of the mitogen-activated protein kinase (MAPK) signaling pathway, is involved in cell survival, differentiation, stress response, and apoptosis. ASK1 kinase inhibition has emerged as a promisin

A modular synthesis of functionalised phenols enabled by controlled boron speciation

A modular synthesis of functionalised biaryl phenols from two boronic acid derivatives has been developed via one-pot Suzuki-Miyaura cross-coupling, chemoselective control of boron solution speciation to generate a reactive boronic ester in situ, and oxidation. The utility of this method has been further demonstrated by application in the synthesis of drug molecules and components of organic electronics, as well as within iterative cross-coupling.

PYRIMIDINE PYRAZOLYL DERIVATIVES

The present invention provides compounds of Formula (I) for the treatment of cancer, rheumatoid arthritis and other diseases (I).