108-36-1Relevant articles and documents
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Bunnett,J.F.,Victor,R.R.
, p. 810 - 811 (1968)
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Nature's hydrides: rapid reduction of halocarbons by folate model compounds
Denk, Michael K.,Milutinovi?, Nicholas S.,Marczenko, Katherine M.,Sadowski, Natalie M.,Paschos, Athanasios
, p. 1883 - 1887 (2017)
Halocarbons R-X are reduced to hydrocarbons R-H by folate model compounds under biomimetic conditions. The reactions correspond to a halide-hydride exchange with the methylenetetrahydrofolate (MTHF) models acting as hydride donors. The MTHF models are also functional equivalents of dehalohydrogenases but, unlike these enzymes, do not require a metal cofactor. The reactions suggest that halocarbons have the potential to act as endocrinological disruptors of biochemical pathways involving MTHF. As a case in point, we observe the rapid reaction of the MTHF models with the inhalation anaesthetic halothane. The ready synthetic accessibility of the MTHF models as well as their dehalogenation activity in the presence of air and moisture allow for the remediation of toxic, halogenated hydrocarbons.
Oxidative bromination of non-activated aromatic compounds with AlBr3/KNO3 mixture
Rahu, Ida,J?rv, Jaak
, p. 1219 - 1227 (2019/11/13)
Bromination of non-activated aromatic compounds with reaction mixture containing KNO3 and AlBr3 was studied in liquid substrates and in solvent. Aluminium bromide has three different roles in this reaction mixture. First, it is a source of bromide ions, which are essential in oxidative bromination application. Second, it acts as a catalyst, and lastly, it forms acidic environment via its hydrolysis, which is necessary for enhancement of the oxidising properties of nitrate ions. It was shown that when changing the reaction conditions, different side reactions (like nitration or Friedel–Crafts type arylation) can occur. However, it is possible to guide the reaction path and receive the desired outcome by choosing the suitable reaction conditions. In addition, it was shown that there has to be water content in this reaction mixture as the bromine formation rate depends on it, while there exists an optimal volume of water, where bromine formation is the fastest.
Preparation method of M-dibromobenzene
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Paragraph 0010-0015, (2019/09/17)
The invention provides a preparation method of m-dibromobenzene. The preparation method comprises the following steps: (1) adding a strong acid into 2,4-dibromoaniline or 2,6-dibromoaniline, then adding a sodium nitrite aqueous solution to performing diazotization reaction on the 2,4-dibromoaniline or 2,6-dibromoaniline at low temperature and acid conditions, and preparing diazo dibromoaniline salt aqueous solution after the reaction is completed; (2) adding a reducing agent into the diazo dibromoaniline salt aqueous solution prepared in the step (1), and enabling the system to react fully toprepare an m-dibromobenzene-containing mixed liquid; (3) standing to layer the mixed liquid prepared in the step (2), then separating an inorganic phase from an organic phase, and distilling the organic phase to obtain the m-dibromobenzene. The method is simple in process steps; the obtained product is low in production cost.