Partial synthesis of major human metabolites of docetaxel
The structures and synthesis of the four major human metabolites of docetaxel are reported. These metabolites, i.e. compounds 3, 4a,b and 5, are side-chain oxidation derivatives. They were prepared by partial synthesis from the previously described amino-taxoid 8 using mixed-carbonates as acylation reagents. In vitro biological activities are detailed.
Commercon, Alain,Bourzat, Jean-Dominique,Bezard, Daniel,Vuilhorgne, Marc
p. 10289 - 10298
(2007/10/02)
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