- COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS
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Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.
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Paragraph 0078; 0079
(2018/04/20)
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- HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF
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The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease.
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Paragraph 0440; 0441; 0442
(2017/07/15)
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- N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES
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This invention relates to compounds of the formula 1 wherein R1, R2, R7, R8, R9, U, V, Z, A, W, X, M, E, L, T and D are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.
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Page/Page column 63
(2010/02/12)
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- Heteroaryl piperazine antipsychotic agents
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Compounds of the formula STR1 and pharmaceutical compositions comprising them, wherein R1, Z, X, W and Y are as defined below. The compounds are useful in the treatment of psychosis and anxiety.
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