- Microwave-assisted rapid electrophilic fluorination of 1,3-dicarbonyl derivatives with Selectfluor
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A microwave-assisted fluorination method for 1,3-dicarbonyl compounds using Selectfluor has been developed. 2-Monofluorinated products can be obtained in high yield in neutral reaction conditions with addition of 1 eq. of Selectfluor. Treatment of 1,3-dicarbonyls with 3 eq. of Selectfluor in the presence of tetrabutylammonium hydroxide (TBAH) as the base results in the formation of 2,2-difluorinated derivatives only.
- Xiao, Ji-Chang,Shreeve, Jean'ne M.
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p. 475 - 478
(2007/10/03)
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- Efficient Electrophilic Fluorination of β-Dicarbonyl Compounds with the Selectfluor Reagent F-TEDA-BF4 octane bis(tetrafluoroborate)>
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1,3-Dicarbonyl compounds (acyclic and cyclic 1,3-diketones, β-ketoesters, β-ketoamides) are converted efficiently to 2-monofluoro derivatives, and thence to 2,2-difluoro derivatives, with 1-chloromethyl-4-fluoro-1,4-diazoniabicyclooctane bis(tetrafluoroborate).
- Banks, R. Eric,Lawrence, Nicholas J.,Popplewell, Allan L.
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p. 343 - 344
(2007/10/02)
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