154483-81-5

Basic information

• Product Name: BOC-PPA(ET)2-OH
• Synonyms: BOC-4-PHOSPHONO-PHE(ET)2-OH;BOC-PPA(ET)2-OH;Nα-Boc-4-(diethoxyphosphinyl)-L-phenylalanine
• CAS NO: 154483-81-5
• Molecular Formula: C₁₈H₂₈NO₇P
• Molecular Weight: 401.393
• Mol File: 154483-81-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BOC-PPA(ET)2-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-PPA(ET)2-OH(154483-81-5)
• EPA Substance Registry System: BOC-PPA(ET)2-OH(154483-81-5)

Safety Data

• Hazardous Substances Data: 154483-81-5(Hazardous Substances Data)

Upstream product

• 112766-18-4 methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-L-tyrosinate 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 154483-79-1 N^α-Boc-4-(diethoxyphosphinyl)-L-phenylalanine methyl ester 

Downstream Products

• 107658-38-8 (S)-2-Amino-3-[4-(diethoxy-phosphoryl)-phenyl]-propionic acid 

Relevant articles and documents

SUBSTITUTED 2-PHENYL-PYRIDINE DERIVATIVES

The present invention relates to compounds of formula I wherein R1, R2, R4, R5, Ra, Rb, n, W and Z are as defined in the application, their preparation and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

PHOSPHONIC ACID DERIVATES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS

The invention relates to 2-phenyl-pyrimidine derivatives containing a phosphonic acid motif and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals. (I).

SUBSTITUTED 2-PHENYL-PYRIDINE DERIVATIVES

The present invention relates to compounds of formula (I) wherein R1, R2, R4, R5, Ra, Rb, n, W and Z are as defined in the application, their preparation and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

New- Nα-Guanidinobenzoyl Derivatives of Hirudin-54-65 Containing Stabilized Carboxyl or Phosphoryl Groups on the Side Chain of Phenylalanine-63

We report on the synthesis and pharmacological properties of a new series of thrombin inhibitors derived from hirudin carboxyl-terminal fragments.Two (arylphosphono)phenylalanines, p-PO3H2-L-Phe1 and m-PO3H2-L-Tyr, and one (carboxymethyl)phenylalanine, p-CH2COOH-L-Phe, were prepared and incorporated into position 63 of the modified hirudin's C-terminal dodecapeptide using the Fmoc solid-phase synthesis strategy.Substitution by any one of the residues led to very active analogs which doubled the thrombin time at low micromolar concentration (Ctt2) in vitro (1 μM 2 3 μM) and potently increased the activated partial thromboplastin time (APTT) ex vivo.These compounds displayed a higher potency in vitro and a longer duration of action in vivo than both the corresponding sulfated or phosphorylated tyrosine counterparts.