- The synthesis of amino acid pyridoxyl esters
-
A multifunctional protective group was suggested on the basis of 4,5-dihydroxymethyl-3-hydroxy-2-methylpyridine (pyridoxine). A preparative method for the synthesis of the starting compounds, pyridoxine ketals, with the use of thionyl chloride was developed, and some new amino acid derivatives, 3,4′-O-isopropylidene-5′-pyridoxyl and 3,4′-O-cyclohexylidene-5′-pyridoxyl esters, were obtained. These resist the action of trifluoroacetic, hydrochloric, hydrobromic, and hydrofluoric acids and can be cleaved by saponification, ammonolysis, hydrazinolysis, hydrogenolysis, or photolysis.
- Sklyarov,Sbitneva,Kopina
-
p. 571 - 578
(2007/10/03)
-
- Optically Active Compounds Derived from Salicylaldehyde and Pyridoxal: Syntheses and Their Chelate Formation Properties in the Interaction with α-Amino Acid
-
Synthesis of chiral compounds derived from salicylaldehyde and pyridoxal was carried out.In aqueous media containing copper ion, these compounds were analyzed to form Schiff base copper chelate spontaneously with α-amino acid.This complex formation process was reversed by the addition of EDTA.Application of the compounds to the resolution of α-amino acids are discussed.
- Tanizawa, Kazutaka,Ichikawa, Yoshihiro,Toyota, Eiko,Chinen, Cisako,Kanaoka, Yuichi
-
p. 415 - 422
(2007/10/02)
-