154564-91-7Relevant academic research and scientific papers
The synthesis of amino acid pyridoxyl esters
Sklyarov,Sbitneva,Kopina
, p. 571 - 578 (2007/10/03)
A multifunctional protective group was suggested on the basis of 4,5-dihydroxymethyl-3-hydroxy-2-methylpyridine (pyridoxine). A preparative method for the synthesis of the starting compounds, pyridoxine ketals, with the use of thionyl chloride was developed, and some new amino acid derivatives, 3,4′-O-isopropylidene-5′-pyridoxyl and 3,4′-O-cyclohexylidene-5′-pyridoxyl esters, were obtained. These resist the action of trifluoroacetic, hydrochloric, hydrobromic, and hydrofluoric acids and can be cleaved by saponification, ammonolysis, hydrazinolysis, hydrogenolysis, or photolysis.
Optically Active Compounds Derived from Salicylaldehyde and Pyridoxal: Syntheses and Their Chelate Formation Properties in the Interaction with α-Amino Acid
Tanizawa, Kazutaka,Ichikawa, Yoshihiro,Toyota, Eiko,Chinen, Cisako,Kanaoka, Yuichi
, p. 415 - 422 (2007/10/02)
Synthesis of chiral compounds derived from salicylaldehyde and pyridoxal was carried out.In aqueous media containing copper ion, these compounds were analyzed to form Schiff base copper chelate spontaneously with α-amino acid.This complex formation process was reversed by the addition of EDTA.Application of the compounds to the resolution of α-amino acids are discussed.
