154564-91-7Relevant articles and documents
The synthesis of amino acid pyridoxyl esters
Sklyarov,Sbitneva,Kopina
, p. 571 - 578 (2007/10/03)
A multifunctional protective group was suggested on the basis of 4,5-dihydroxymethyl-3-hydroxy-2-methylpyridine (pyridoxine). A preparative method for the synthesis of the starting compounds, pyridoxine ketals, with the use of thionyl chloride was developed, and some new amino acid derivatives, 3,4′-O-isopropylidene-5′-pyridoxyl and 3,4′-O-cyclohexylidene-5′-pyridoxyl esters, were obtained. These resist the action of trifluoroacetic, hydrochloric, hydrobromic, and hydrofluoric acids and can be cleaved by saponification, ammonolysis, hydrazinolysis, hydrogenolysis, or photolysis.