154660-96-5

Basic information

• Product Name: 1H-Benzimidazole,2-[(2,4-dichlorophenyl)methyl]-
• Synonyms: 1H-Benzimidazole,2-[(2,4-dichlorophenyl)methyl]-;2-(2,4-Dichlorobenzyl)-1H-benzimidazole;2-[(2,4-Dichlorophenyl)methyl]-1H-benzimidazole;2-(2,4-Dichlorobenzyl)benziMidazole;2-(2,4-Dichlorobenzyl)-1H-benzo[d]imidazole;2-(2,4-two chlorobenzyl)benziMidazole;2-[(2,4-Dichlorophenyl)methyl]-1H-benzimid;2-(2,4-Dichlorobenzyl)-1H-b
• CAS NO: 154660-96-5
• Molecular Formula: C14H10Cl2N2
• Molecular Weight: 277.15
• EINECS: 1308068-626-2
• Mol File: 154660-96-5.mol

Chemical Properties

• Boiling Point: 503.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.396
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.58±0.10(Predicted)
• CAS DataBase Reference: 1H-Benzimidazole,2-[(2,4-dichlorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,2-[(2,4-dichlorophenyl)methyl]-(154660-96-5)
• EPA Substance Registry System: 1H-Benzimidazole,2-[(2,4-dichlorophenyl)methyl]-(154660-96-5)

Safety Data

• Hazardous Substances Data: 154660-96-5(Hazardous Substances Data)

Usage

Chemical Properties

White crystals

Upstream product

• 19719-28-9 2,4-dichlorophenylacetic acid 
• 95-54-5 1,2-diamino-benzene 
• 5922-21-4 ethyl 2-(2,4-dichlorophenyl)acetimidate hydrochloride 
• 6306-60-1 2,4-Dichlorophenylacetonitrile 

Relevant articles and documents

Synthesis method of benzimidazole derivative

The invention discloses a synthesis method of a benzimidazole derivative. The method comprises the following steps: o-phenylenediamine or a derivative thereof and phenylacetic acid or a derivative ofthe phenylacetic acid are used as raw materials, a composite solid catalyst is adopted, and a high-boiling-point organic solvent is taken as a reaction solvent for carrying out a reaction at 100-130 DEG C for 4-8 hours; and distillation, dissolution, neutralization, decoloration and recrystallization are carried out to obtain a benzimidazole derivative product. The method has the advantages that operation is simple, the reaction time is greatly shortened, the product color is good, the yield is high, cost is low, pollution is low, environment friendliness is achieved, and the like, and has a very good industrial production application prospect.

A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies

A novel series of benzimidazole derivatives were prepared starting from o-phenylenediamine and 4-nitro-o-phenylenediamine with iminoester hydrochlorides. Acidic proton in benzimidazole was exchanged with ethyl bromoacetate, then ethyl ester group was transformed into hydrazide group. Cyclization using CS2/KOH leads to the corresponding 1,3,4-oxadiazole derivative, which was treated with phenyl isothiocyanate resulted in carbothioamide group, respectively. As the target compounds, triazole derivative was obtained under basic condition and thiadiazole derivative was obtained under acidic condition from cyclization of carbothioamide group. Most reactions were conducted using both the microwave and conventional methods to compare yields and reaction times. All compounds obtained in this study were investigated for α-glucosidase inhibitor activity. Compounds 6a, 8a, 4b, 5b, 6b and 7b were potent inhibitors with IC50 values ranging from 10.49 to 158.2?μM. This has described a new class of α-glucosidase inhibitors. Molecular docking studies were done for all compounds to identify important binding modes responsible for inhibition activity of α-glucosidase.