A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity
Humanin (HN), a 24-amino acid bioactive peptide, has been shown to increase cell survival of neurons after exposure to Aβ and NMDA-induced toxicity and thus could be beneficial in the treatment of Alzheimer's disease (AD). The neuroprotection by HN is rep
Alam, Mohammad Parvez,Bilousova, Tina,Spilman, Patricia,Vadivel, Kanagasabai,Bai, Dongsheng,Elias, Chris J.,Evseenko, Denis,John, Varghese
p. 462 - 468
(2018/03/27)
GP130 MODULATORS
There are provided, inter alia, compounds and methods useful for the treatment of neurological conditions, such as neurological disorders and neurodegenerative diseases, including Alzheimer's Disease.
-
Paragraph 0321-0322
(2018/03/28)
SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF
The present invention relates to novel substituted 4-arylthiazoles, their preparation, and to their use as therapeutic agents, particularly in the prevention or treatment of tuberculosis. The resent invention articularl relates to com ounds of formula A:
-
(2013/02/28)
Synthesis and biological evaluation of substituted 4-arylthiazol-2-amino derivatives as potent growth inhibitors of replicating Mycobacterium tuberculosis H37RV
In search of potential therapeutics for tuberculosis, we describe herein synthesis and biological evaluation of some substituted 4-arylthiazol-2-amino derivatives as modified analogues of the antiprotozoal drug Nitazoxanide (NTZ), which has recently been reported as potent inhibitor of Mtb H37Rv (Mtb MIC = 52.12 μM) with an excellent ability to evade resistance. Among the synthesized derivatives, the two compounds 7a (MIC = 15.28 μM) and 7c (MIC = 17.03 μM) have exhibited about three times better Mtb growth inhibitory activity over NTZ and are free from any cytotoxicity (Vero CC50 of 244 and 300 μM respectively). These two compounds represent promising leads for further optimization.
Roy, Kuldeep K.,Singh, Supriya,Sharma, Sandeep K.,Srivastava, Ranjana,Chaturvedi, Vinita,Saxena, Anil K.
p. 5589 - 5593
(2011/10/12)
Organoiodine(III) mediated one-pot synthesis of N-substituted 2-aminothiazoles
The synthesis of N-substituted 2-aminothiazoles has been achieved in one-pot by the successive treatment of acetophenones with [hydroxy(tosyloxy) iodo)benzene (HTIB), potassium thiocyanate and appropriate aniline.
Prakash, Om,Pundeer, Rashmi,Chaudhri, Vishwas
p. 786 - 788
(2007/10/03)
Synthesis of some new fluorine containing 2-(N-arylamino)/2-methyl-4-aryl thiazoles and their bactericidal activity
-
Joshi,Pathak,Arya
p. 199 - 201
(2007/10/04)
More Articles about upstream products of 1554-59-2