- Reactivity of hydroxy and amino derivatives of 2-phenyl-1H-imidazoline and 2-phenyl-1H-imidazole toward isocyanates: Synthesis of appropriate carbamates and ureas
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Reactivity of 2-(4-hydroxyphenyl)-1H-imidazoline and 2-(4-hydroxyphenyl)- 1H-imidazole toward substituted phenyl isocyanates was studied. When mentioned imidazoline was treated with 2.5 equiv of substituted phenyl isocyanate, three N,O-dicarboxamides were
- Parik, Patrik,Jansa, Josef,Holesova, Sylva,Marek, Ales,Klimesova, Vera
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p. 903 - 910
(2013/08/23)
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- Synthesis and biological evaluation of novel 2-(4-O-β-D- glucosidoxyphenyl)-4,5-disubstituted imidazoles
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A series of 2-(4-hydroxyphenyl)-4,5-disubstituted imidazoles (1a-e) prepared from α-diketones, ammonium acetate, and p-hydroxybenzaldehyde, which were glucosylated by using α-acetobromoglucose to form 2-(4-O-β-D-2,3,4,6-tetra-O-acetyl-glucosidoxyphenyl)-4
- Taile,Hatzade,Gaidhane,Ingle
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experimental part
p. 903 - 907
(2010/10/18)
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- Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives
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Two series of novel diaryl ureas have been designed and synthesized, with their in vitro antitumor effect screened on human non-small cell lung cancer (NSCLC) cell line A549 and human breast cancer cell line MDA-MB-231. Some target compounds demonstrated significant inhibitory activities against both cell lines. Compared to contrast drug Sorafenib, 1b, 1d, 1f, 1i were found to demonstrate more potent antitumor activities. The structures of all the newly synthesized compounds were determined by 1H, 13C NMR, MS, IR and elementary analysis.
- Sun, Min,Wu, Xiaoqing,Chen, Junqing,Cai, Jin,Cao, Meng,Ji, Min
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experimental part
p. 2299 - 2306
(2010/07/05)
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- Synthesis and analgesic-antiinflammatory activity of some 4- and 5-substituted heteroarylsalicylic acids
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We have made a series of 4- and 5-aryl- and 4- and 5-heteroarylsalicylic acid derivatives with the objective of reducing gastric irritation and increasing potency. Here we describe a series of 4- and 5-heterocyclic salicylic acids and their antiinflammatory-analgesic potencies measured in comparison to aspirin. An improvement of the therapeutic index over aspirin of 100 was achieved; however, the heterocyclic salicylic acids lacked antipyretic activity. Some physicochemical parameters which may bear on the antiinflammatory activity of these compounds are discussed.
- Jones,Fordice,Greenwald,Hannah,Jacobs,Ruyle,Walford,Shen
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p. 1100 - 1104
(2007/10/05)
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