15548-89-7

Usage

Uses

Used in Pharmaceutical Industry:
Phenol, 4-(1H-imidazol-2-yl)is used as a chemical intermediate for the synthesis of various drugs, particularly in the development of antifungal and antiviral medications. Its unique structure allows for the creation of new therapeutic agents that can target specific biological pathways.
Used in Coordination Chemistry:
In coordination chemistry, Phenol, 4-(1H-imidazol-2-yl)is utilized as a potential ligand. Its ability to form stable complexes with metal ions makes it a valuable component in the design of new coordination compounds with specific properties and applications.
Used in Organic Synthesis:
Phenol, 4-(1H-imidazol-2-yl)serves as a building block in organic synthesis, contributing to the creation of a wide range of organic compounds with diverse functionalities and applications.
Used in Biochemical Research:
Phenol, 4-(1H-imidazol-2-yl)has been investigated for its potential biological activities in biochemical research. Its unique structure and properties make it a candidate for studying various biological processes and interactions, potentially leading to new insights and applications in the life sciences.

Upstream product

• 52091-37-9 2-[4-(methyloxy)phenyl]-1H-imidazole 
• 212485-91-1 2-(4-hydroxyphenyl)-4,5-dihydro-1H-imidazole 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 90437-28-8 N-(2-aminoethyl)-4-hydroxybenzamide 
• 131543-46-9 Glyoxal 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 1228885-78-6 2-[4-(4-nitrophenoxy)phenyl]imidazole 

Relevant academic research and scientific papers

Reactivity of hydroxy and amino derivatives of 2-phenyl-1H-imidazoline and 2-phenyl-1H-imidazole toward isocyanates: Synthesis of appropriate carbamates and ureas

Reactivity of 2-(4-hydroxyphenyl)-1H-imidazoline and 2-(4-hydroxyphenyl)- 1H-imidazole toward substituted phenyl isocyanates was studied. When mentioned imidazoline was treated with 2.5 equiv of substituted phenyl isocyanate, three N,O-dicarboxamides were

Synthesis and biological evaluation of novel 2-(4-O-β-D- glucosidoxyphenyl)-4,5-disubstituted imidazoles

A series of 2-(4-hydroxyphenyl)-4,5-disubstituted imidazoles (1a-e) prepared from α-diketones, ammonium acetate, and p-hydroxybenzaldehyde, which were glucosylated by using α-acetobromoglucose to form 2-(4-O-β-D-2,3,4,6-tetra-O-acetyl-glucosidoxyphenyl)-4

Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives

Two series of novel diaryl ureas have been designed and synthesized, with their in vitro antitumor effect screened on human non-small cell lung cancer (NSCLC) cell line A549 and human breast cancer cell line MDA-MB-231. Some target compounds demonstrated significant inhibitory activities against both cell lines. Compared to contrast drug Sorafenib, 1b, 1d, 1f, 1i were found to demonstrate more potent antitumor activities. The structures of all the newly synthesized compounds were determined by 1H, 13C NMR, MS, IR and elementary analysis.

Synthesis and analgesic-antiinflammatory activity of some 4- and 5-substituted heteroarylsalicylic acids

We have made a series of 4- and 5-aryl- and 4- and 5-heteroarylsalicylic acid derivatives with the objective of reducing gastric irritation and increasing potency. Here we describe a series of 4- and 5-heterocyclic salicylic acids and their antiinflammatory-analgesic potencies measured in comparison to aspirin. An improvement of the therapeutic index over aspirin of 100 was achieved; however, the heterocyclic salicylic acids lacked antipyretic activity. Some physicochemical parameters which may bear on the antiinflammatory activity of these compounds are discussed.