- Gold-based immunochromatographic strip assay for detecting dimethomorph in vegetables
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Dimethomorph (DMM) is a novel therapeutic fungicide, which is mainly used to control downy mildew, phytophthora, and other fungal diseases of grapes, leeks, and cucumbers. Its residue is harmful to the human body and the soil environment. In this study, the optimum monoclonal antibody (mAb) against DMM was prepared after routine fusion and selection. Based on the mAb, an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) and a gold nanoparticle immunochromatographic assay (GNP-ICA) were developed for detecting DMM in leek samples. The 50% inhibitory concentration (IC50) of the mAb was 1.823 ng mL-1, and its cross-reactivity with structurally related analogs was less than 3%. Under optimal conditions, the visible detection limit of this ICA method was 10 ng g-1, and the cutoff value of DMM in leeks was 100 ng g-1. The analysis of DMM in leeks showed that the results of the strip analysis were highly comparable with those of ic-ELISA and liquid chromatography-mass spectrometry LC-MS. Therefore, the GNP immunoassay is a sensitive screening method for detecting DMM residues in foods.
- Kuang, Hua,Liu, Liqiang,Xiang, Tongyue,Xu, Chuanlai,Xu, Liguang,Xu, Xinxin
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p. 3882 - 3888
(2022/03/07)
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- One-Pot Direct Synthesis of Weinreb Amides from Aryl and Hetero Aryl Halides Using Co 2(CO) 8 as an Effective CO Source under Conventional Thermal Heating
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A successful protocol for the synthesis of Weinreb amides directly from aryl halides via aminocarbonylation with N,O-dimethyl hydroxylamine using Co2(CO)8 as an in situ CO source has been demonstrated. The effects of various reaction parameters such as temperature, base, and CO source have also been investigated and optimized. GRAPHICAL ABSTRACT.
- Baburajan, Poongavanam,Elango, Kuppanagounder P.
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p. 541 - 548
(2015/10/29)
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- An Efficient synthesis of Weinreb amides and ketones via palladium nanoparticles on ZIF-8 catalysed carbonylative coupling
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Heterogeneously catalysed carbonylative coupling reactions such as aminocarbonylation and Suzuki-carbonylation are reported using Pd nanoparticles supported on ZIF-8 for efficient and environmentally attractive synthesis of Weinreb amides and ketones from aryl bromides or iodides. The catalyst is air stable, offers high activity with very low palladium leaching and is recyclable. The presence of a phosphine ligand was required when aryl bromides were used as substrates, while no ligand was necessary when aryl iodides were used. the Partner Organisations 2014.
- Thanh Dang, Tuan,Chen, Anqi,Majeed Seayad, Abdul
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p. 30019 - 30027
(2014/08/05)
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- Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents
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KPU-105 (4), a potent anti-microtubule agent that contains a benzophenone was derived from the diketopiperazine-type vascular disrupting agent (VDA) plinabulin 3, which displays colchicine-like tubulin depolymerization activity. To develop derivatives wit
- Hayashi, Yoshio,Yamazaki, Yuri,Sumikura, Makiko,Masuda, Yurika,Hayashi, Yoshiki,Yasui, Hiroyuki,Kiso, Yoshiaki,Chinen, Takumi,Usui, Takeo,Yakushiji, Fumika,Potts, Barbara,Neuteboom, Saskia,Palladino, Michael,Lloyd, George Kenneth
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experimental part
p. 4279 - 4289
(2012/09/08)
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- Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors
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A series of 3-aryl-3-azolylpropan-1-amines was prepared and screened for its capability of inhibiting monoamine reuptake. Analogs with nanomolar potency, good human in vitro microsomal stability, and low drug-drug interaction potential were described. In
- Lee, Ki-Ho,Park, Chun-Eung,Min, Kyung-Hyun,Shin, Yong-Je,Chung, Coo-Min,Kim, Hui-Ho,Yoon, Hae-Jeoung,Won-Kim,Ryu, Eun-Ju,Shin, Yu-Jin,Nam, Hyun-Sik,Cho, Jeong-Woo,Lee, Hee-Yoon
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scheme or table
p. 5567 - 5571
(2010/12/29)
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- Simple synthesis of amides and weinreb amides Using PPh3 or PolymerSupported PPh3 and Iodine
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The combination of PPh3/I2 has been shown to be effective for the conversion of a range of carboxylic acids into secondary, tertiary, and Weinreb amides. Simplification of the procedure was possible with the use of polymer-supported PPh3/ I2. Weinreb amides produced with the use of polymer-supported PPh3 could be filtered through a short silica gel plug and used in further transformations. Thus, the use of polymer-supported PPh3 offers potential applicability to diversityoriented reactions. Formal total syntheses of apocynin and pratosine, as well as syntheses of anhydrolychorinone and hippadine, have been achieved through the use of this amide-forming method. An attempt has been made to gain insight into this reaction.
- Kumar, Amit,Akula, Hari Kiran,Lakshman, Mahesh K.
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experimental part
p. 2709 - 2715
(2010/08/05)
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- Palladium-catalyzed carbonylation reactions of aryl bromides at atmospheric pressure: A general system based on xantphos
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(Chemical Equation Presented) A method for the Pd-catalyzed carbonylation of aryl bromides has been developed using Xantphos as the ligand. This method is effective for the direct synthesis of Weinreb amides, 1° and 2° benzamides, and methyl esters from the corresponding aryl bromides at atmospheric pressure. In addition, a putative catalytic intermediate, (Xanphos)Pd(Br)benzoyl, was prepared and an X-ray crystal structure was obtained revealing an unusual cis-coordination mode of Xantphos in this palladium-acyl complex.
- Martinelli, Joseph R.,Watson, Donald A.,Freckmann, Dominique M. M.,Barder, Timothy E.,Buchwald, Stephen L.
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supporting information; experimental part
p. 7102 - 7107
(2009/05/09)
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- Convenient method for the preparation of weinreb amides via PD-catalyzed aminocarbonylation of aryl bromides at atmospheric pressure
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(Chemical Equation Presented) The direct transformation of aryl bromides into the corresponding Weinreb amides via Pd-catalyzed aminocarbonylation at atmospheric pressure is reported.
- Martinelli, Joseph R.,Freckmann, Dominique M. M.,Buchwald, Stephen L.
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p. 4843 - 4846
(2007/10/03)
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