155773-72-1Relevant articles and documents
Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers
Yiyun, Cheng,Tongwen, Xu
, p. 1188 - 1192 (2005)
The aqueous solubility of non-steroidal anti-inflammatory drugs (NSAIDs) Ketoprofen, Ibuprofen, Diflunisal and Naproxen were measured in the presence of the ethylenediamine (EDA) core polyamidoamine (PAMAM) dendrimers at 37°C. The effect of concentration and generation of the PAMAM dendrimers has been investigated. Results showed that the solubility of NSAIDs in the PAMAM dendrimer solutions was approximately proportional to dendrimer concentration; the solubility of NSAIDs in higher generation PAMAM solutions was in fact higher that those in lower ones; the order of increased solubility of NSAIDs in PAMAM dendrimers at a constant dendrimer concentration and generation was Naproxen > Ketoprofen > Ibuprofen > Diflunisal. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of NSAIDs.
Surface modified PAMAM dendrimers with gallic acid inhibit, cell proliferation, cell migration and inflammatory response to augment apoptotic cell death in human colon carcinoma cells
Priyadarshi, Khushbu,Shirsath, Kavita,Waghela, N. Bhargav,Sharma, Anupama,Kumar, Ajay,Pathak, Chandramani
, p. 6853 - 6869 (2021)
To overcome the obstacle of anti-cancer therapy significant attention has been drawn for improving drug delivery system. Since recent past, different approaches were applied using synthetic or natural derivatives for improving efficacy of anti-cancer drugs in cancer therapeutics. Gallic acid (GA) is a natural polyphenol, which exhibits a broad spectrum of biological activities, but its therapeutic application was limited due to poor bioavailability and toxicity. In the present study, we had conjugated the GA with PAMAM dendrimers and proposed the insights of molecular mechanism on inhibition of cell proliferation and programmed cell death through apoptotic pathway in human colon carcinoma cells. GA was chemically conjugated with 4.0 G PAMAM dendrimer at outer surface and characterized by different biophysical methods. We further examined its bioavailability, anti-cancer activity and explored the molecular mechanism of programmed cell death signaling in HCT116 cells. The results show that PAMAM-GA conjugate inhibits cell proliferation of different origin of cancer cells, improves cellular uptake of GA, inhibits colonogenic ability, restricts cancer cell migration by down regulating the expression of MMP-9, inhibits NF-kB activation and release of pro-inflammatory cytokines to manifest apoptotic cell death in HCT 116 cells rather than necrosis. On other hand, PAMAM-GA conjugate showed negligible cytotoxic response as compared to the free Gallic acid to the normal cells. In conclusion, findings of this study revealed that PAMAM-GA conjugate improves the bioavailability of GA and specificity towards cancer cellsto manifests apoptotic cell death. This indispensable approach may be beneficial for the revolution of anti-cancer therapy. Communicated by Ramaswamy H. Sarma.
The synthesis of water soluble dendrimers, and their application as possible drug delivery systems
Twyman, Lance J.,Beezer, Anthony E.,Esfand,Hardy, Martin J.,Mitchell, John C.
, p. 1743 - 1746 (1999)
The synthesis of two water soluble dendrimers is described. The formation of water soluble inclusion complexes with a variety of small, hydrophobic guest molecules is also described. Moreover, when these guest molecules are drug moieties, then the resulting drug/dendrimer complexes can be considered ideal candidates for use as novel drug delivery systems.
Manganese dioxide-core-shell hyperbranched chitosan (MnO2-HBCs) nano-structured screen printed electrode for enzymatic glucose biosensors
Abd El-Haleem, Hala S.,Hefnawy, Amr,Hassan, Rabeay Y.A.,Badawi, Ashraf H.,El-Sherbiny, Ibrahim M.
, p. 109185 - 109191 (2016)
In this study, the synthesis, characterization and testing of new polymeric-metal oxide nanocomposites for enzymatic glucose biosensors were performed. Among various nano-composites, manganese dioxide-core-shell hyperbranched chitosan (MnO2-HBCs) provided rapid and high efficiency direct electron transfer from the redox active centre of an immobilized enzyme and screen printed electrode. The assay optimization was achieved after testing the effects of several factors such as type of crosslinking agent, accumulation potential, toxicity of heavy metals and interferences on the bioactivity of GOx. Results demonstrated sensitivity of the proposed method to detect inhibition effects of metal ions and also the response of agents interfering with glucose measurement. A chronoamperometric calibration curve was obtained, and the oxidation current of the enzymatically produced H2O2 was linearly dependent on glucose concentration with a detection limit of 7 μg mL-1. Thus, the clinical determination of glucose concentration was performed on blood samples and the results were correlated with a reference method. In conclusion, the current study suggests a new class of electrochemical biosensors and paves the way for further promising applications.
Efficient oral insulin delivery by dendronized chitosan: In vitro and in vivo studies
Mukhopadhyay, Piyasi,Sarkar, Kishor,Bhattacharya, Sourav,Mishra, Roshnara,Kundu
, p. 43890 - 43902 (2014)
The development of efficient and bio-safe polymeric carriers for oral insulin delivery is a major thrust in biomedical research. In this paper, dendronized chitosan (DCTS) is prepared using a Michael-type addition reaction by grafting polyamidoamine (PAMAM) onto chitosan to improve its water solubility, pH sensitivity, and insulin encapsulation efficiency for enhanced bioavailability of the oral insulin. The self-assembled dendronized chitosan nanoparticles are prepared using a mild coacervation method, in which almost sub-spherically shaped nanoparticles of 85-150 nm size are produced, with an insulin encapsulation of approx. 95%. In vitro release study confirms a pH-sensitive and self-sustained release of insulin, where the oral administration of these nanoparticles exhibits a pronounced hypoglycemic effect in diabetic mice, producing a relative bioavailability of ～9.19%. As no systemic toxicity is observed with its peroral delivery, these DCTS nanoparticles can effectively serve as a promising device in the efficient administration of oral insulin. This journal is
Retarding action of poly(amidoamine) dendrimers and cationic gemini surfactants in acrylic dyeing
Sadeghi-Kiakhani, Mousa,Tehrani-Bagha, Ali Reza
, p. 323 - 330 (2016)
Two cationic gemini surfactants and two generations of poly(amidoamine) (PAMAM) dendrimers (G = -0.5 and G = 0.5) were studied as retarders in acrylic dyeing with a cationic dye. Effects of retarder concentrations, dyeing time, and temperature were investigated by means of UV-Vis spectrophotometry. The results indicated that the dye adsorption decreased in the presence of the species and more uniform dyeing was achieved. The PAMAM dendrimers had lower retarding action than the cationic gemini surfactants which was attributed to their non-permanent and lower cationic charge density. Kinetics of the dyeing systems were also evaluated by four different empirical models. The modified Cegarra-Puente model fitted the dyeing kinetic data somewhat better than the other empirical kinetic models. Moreover, the activation energy of the dyeing systems was calculated and reported.
Modified PAMAM dendrimers as a matrix for the photostabilization of curcumin
Dodangeh, Mohammad,Grabchev, Ivo,Gharanjig, Kamaladin,Staneva, Desislava,Tang, Ren-Cheng,Sheridan, Matthew
supporting information, p. 17112 - 17121 (2020/10/27)
Six recently synthesised poly(amidoamine) (PAMAM) dendrimers from zero, first and second generations modified with 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (curcumin) and 2,4-dihydroxybenzophenone (CU-1, CU-2, CU-3, CU-4, CU-5 and CU-6) have been investigated in water/dioxane (4 : 1) (v/v) solution by absorption and fluorescence spectroscopy in order to determine their photostability. It has been found that the photostability of curcumin is enhanced upon its incorporation into the dendrimer molecule, and a new additional stabilization is achieved by bonding of 2,4-dihydroxybenzophenone as a UV absorber to the dendrimer molecule. It has also been established that the generation of dendrimers impacts upon this parameter as the photostabilizing effect enhances at a higher dendrimer generation. The photostability of the dendrimers has also been investigated after their deposition onto a polyethylene terephthalate (PET) fabric. This journal is
Hindered phenol and acylamino intramolecular composite difunctional antioxygen and synthesis method thereof
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Paragraph 0043-0048; 0064-0066; 0072-0074, (2019/11/20)
The invention belongs to the technical field of antioxygens, and particularly relates to a hindered phenol and acylamino intramolecular composite difunctional antioxygen and a synthesis method thereof. The hindered phenol and acylamino intramolecular composite difunctional antioxygen is prepared through the mode that firstly, ethanediamine, methyl alcohol and methyl acrylate are prepared into an ethanediamine dendritic molecule framework, and then the end group of the ethanediamine dendritic molecule framework is subjected to DtBHP closing. The antioxygen forms stable free radicals to end a chain reaction by capturing generated free radicals, the free radicals can be directly, effectively and quickly captured, and the antioxygen is high in antioxygenic capacity.
Antimicrobial efficacy of synthesized quaternary ammonium polyamidoamine dendrimers and dendritic polymer network
Zainul Abid,Jackeray, Richa,Jain, Swati,Chattopadhyay, Sruti,Asif,Singh, Harpal
, p. 998 - 1007 (2016/03/08)
Water treatment to mitigate microbial contaminants is a major challenge across globe paving the way to develop novel antimicrobial compounds. We aim at architecting antibacterial moiety eventually catering to vast water treatment industry. In this research study, quaternary ammonium functionalized polyamidoamine (PAMAM) dendrimer and PAMAM-ethyleneglycol dimethacrylate (EGDMA) dendritic polymer network were synthesized. These materials were characterized by various analytical techniques like ATR-FTIR, 1HNMR, DSC etc. Water soluble generation (G) 1.0 PAMAM dendrimer and water insoluble PAMAM G1.0 EGDMA dendritic polymer network were quaternized by reacting with dilute hydrochloric acid (HCl) and octyl iodide (OI) respectively. Both quaternary ammonium dendrimer products were found to exhibit potent bactericidal activity against a group of common Gram-negative and Gram-positive bacteria. 10 mg/L concentration of liquid PAMAM G1.0 QHCl was efficient to kill 100% bacteria rapidly within an incubation time of just 2 minutes. In addition, quaternary ammonium dendritic polymer network PAMAM G1.0-EGDMA Q OI demonstrated good contact killing antimicrobial property without releasing any active molecule into the surrounding medium and disinfected contaminated water within 5 minutes. Both quaternary ammonium dendrimer and dendritic polymer network showed negligible cytotoxicity in MTT assay indicating their potential as a viable antimicrobial agent.
METHOD FOR SEPARATING FLAVONOID SUBSTANCES IN CAMELLIA NITIDISSIMA CHI BASED ON A MAGNETIC NANOPARTICLES-PAMAM NANO COMPOSITES
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Paragraph 0015, (2016/06/06)
The present invention discloses a method for separating flavonoid substances in Camellia nitidissima Chi based on a magnetic nanoparticles-PAMAM nano composites, which comprises the following steps: preparing PAMAM dendrimer, then using the PAMAM dendrimer to prepare the magnetic nanoparticles-PAMAM nano composites, then adding the obtained magnetic nanoparticles-PAMAM nano composites in a Camellia nitidissima Chi extract, extracting and performing magnetic separation on the flavonoid substances in Camellia nitidissima Chi under ultrasound or microwave condition. According to the present invention, flavonoid substances with faintly acid characteristics are extracted and adsorbed in a plant concentrate such as Camellia nitidissima Chi or Hedyotis diffusa etc. based on the magnetic nanoparticles-PAMAM nano composites, in a successive step, high efficiency separation of the flavonoid substances can be realized by the technologies such as magnetic separation and microwave-assisted extraction.
