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CAS

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15588-95-1

2,5-Dimethoxy-4-Methylamphetamine (DOM, STP) is a synthetic amphetamine derivative known for its dose-dependent psychotomimetic and hallucinogenic properties. It exhibits a strong affinity for serotonin 5-HT2 receptors, making it a compound of interest in various research and forensic applications. Classified as a Schedule I compound in the United States, DOM is primarily used for research purposes.

15588-95-1 Suppliers

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  • 15588-95-1 Structure

  • Basic information

    1. Product Name: 2,5-Dimethoxy-4-Methylamphamin
    2. Synonyms: 2,5-Dimethoxy-4-Methylamphamin;2,5-Dimethoxy-4-Methylamphetamine;DOM (exempt preparation)
    3. CAS NO:15588-95-1
    4. Molecular Formula: C12H19NO2
    5. Molecular Weight: 223.35
    6. EINECS: 205-524-5
    7. Product Categories: Amines;Aromatics
    8. Mol File: 15588-95-1.mol

  • Chemical Properties

    1. Melting Point: 60.5-61°
    2. Boiling Point: 322.7°Cat760mmHg
    3. Flash Point: 162.9°C
    4. Appearance: /
    5. Density: 0.998g/cm3
    6. Vapor Pressure: 0.000274mmHg at 25°C
    7. Refractive Index: 1.509
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 9.77±0.10(Predicted)
    11. CAS DataBase Reference: 2,5-Dimethoxy-4-Methylamphamin(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2,5-Dimethoxy-4-Methylamphamin(15588-95-1)
    13. EPA Substance Registry System: 2,5-Dimethoxy-4-Methylamphamin(15588-95-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 15588-95-1(Hazardous Substances Data)

15588-95-1 Usage

Uses

Used in Research and Forensic Applications:
2,5-Dimethoxy-4-Methylamphetamine is used as a research compound for studying the effects of its potent binding and activation of serotonin 5-HT2 receptors. This application aids in understanding the underlying mechanisms of its psychotomimetic and hallucinogenic properties, which can be valuable in the development of new therapeutic approaches for various psychiatric and neurological disorders.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2,5-Dimethoxy-4-Methylamphetamine is used as a starting point for the development of new drugs targeting serotonin 5-HT2 receptors. Its interaction with these receptors provides insights into potential therapeutic applications, such as the treatment of depression, anxiety, and other mood disorders.
Used in Neuropharmacological Studies:
2,5-Dimethoxy-4-Methylamphetamine is used as a tool in neuropharmacological research to investigate the role of serotonin 5-HT2 receptors in the central nervous system. This helps researchers to better understand the complex interactions between neurotransmitters and their receptors, which can contribute to the development of more effective medications for a range of neurological conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 15588-95-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,5,8 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 15588-95:
(7*1)+(6*5)+(5*5)+(4*8)+(3*8)+(2*9)+(1*5)=141
141 % 10 = 1
So 15588-95-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H21NO2/c1-5-10-7-13(16-4)11(6-9(2)14)8-12(10)15-3/h7-9H,5-6,14H2,1-4H3

15588-95-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,5-Dimethoxy-4-methylamphetamine

1.2 Other means of identification

Product number -
Other names 2,5-dimethoxy-4-methylphenylisopropylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15588-95-1 SDS

15588-95-1Relevant articles and documents

Stereospecific synthesis of amphetamines

Wagner, Jared M.,McElhinny Jr., Charles J.,Lewin, Anita H.,Carroll, F. Ivy

, p. 2119 - 2125 (2007/10/03)

Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine.

Binding of Phenylalkylamine Derivatives at 5-HT1C and 5-HT2 Serotonin Receptors: Evidence for a Lack of Selectivity

Glennon, Richard A.,Raghupathi, Reva,Bartyzel, Piotr,Teitler, Milt,Leonhardt, Sigrun

, p. 734 - 740 (2007/10/02)

Certain phenyalkylamine derivatives have been considered to bind selectively at 5-HT2 serotonin receptors.It is now recognized that the most widely used derivatives, i.e., 1-(2,5-dimethoxy-4-X-phenyl)-2-aminopropanes where X = Me (DOM), Br (DOB), and I (DOI) (1-3, respectively) also bind at the more recently identified population of serotonin 5-HT1C receptors.The purpose of the present investigation was to determine whether simple phenylalkylamines bind selectively at one population of receptors over the other.An examination of 34 derivatives reveals (i) similar structure-affinity relationships and (ii) a significant correlation (r = >0.9, n = 25) between 5-HT1C and 5-HT2 affinity.None of the compounds included in the present study displayed more than a 10-fold selectivity for one population of these receptors over the other; the results suggest that these compounds (including the widely used 5-HT2 agonists DOB and DOI) are 5-HT1C/5-HT2 agents.