43061-14-9

Upstream product

• 4925-88-6 2,5-dimethoxy-4-methylbenzaldehyde 
• 15588-95-1 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane 
• 609771-66-6 (2S)-1-(2',5'-dimethoxy-4'-methylphenyl)-2-propanol 
• 13321-74-9 1-bromo-2,5-dimethoxy-4-methylbenzene 
• 24599-58-4 2,5-dimethoxy toluene 
• 609771-68-8 (2S)-1-(2,5-dimethoxy-4-methylphenyl)-2-propyl azide 
• 29907-72-0 1-(2,5-Dimethoxy-4-methyl-phenyl)-2-nitro-propen 

Downstream Products

• 76124-14-6 (S)-2-(2,5-dimethoxy-4-methylphenyl)-2-<(benzoyloxy)amino>propane 
• 51267-05-1 (S)-1-(2,5-dimethoxy-4-methylphenyl)-2-(hydroxyamino)propane hydrochloride 

Relevant academic research and scientific papers

Stereospecific synthesis of amphetamines

Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine.

Asymmetric synthesis of phenylisopropylamines

The synthesis of enantiomers of a series of methoxy- and alkyl- substituted phenylisopropylamines is described. The synthesis comprises reducing the imines, formed by the reaction of appropriate phenylacetones with either (+)- or (-)-α-methylbenzylamine, by low-pressure reduction techniques, and subsequently subjecting the optically active N-(α-phenethyl)phenylisopropylamine derivative to hydrogenolysis. The hydrogenolysis products are characterized by enantiomeric purities in the range of 96 - 99%. Yields of products are approximately 60%.