156-87-6Relevant academic research and scientific papers
Novel applications of Raney nickel/isopropanol: Efficient system for the reduction of organic compounds
Regla, Ignacio,Reyes, Adelfo,Koerber, Claudia,Demare, Patricia,Estrada, Osvaldo,Juaristi, Eusebio
, p. 817 - 823 (1997)
Catalytic hydrogenation of various organic substrates with Raney nickle in isopropanol proceeds under mild conditions of temperature and pressure. Comparison with other catalysts systems evidenced the superiority of Raney nickel/isopropanol.
Method for preparing gamma-aminopropanol through one-step catalytic hydrogenation and application of gamma-aminopropanol
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Paragraph 0011-0018, (2021/07/17)
The invention relates to a method for preparing gamma-aminopropanol through one-step catalytic hydrogenation, which comprises the following step: in the presence of a metal catalyst, beta-alanine and hydrogen are subjected to hydrogenation reaction in a reaction solvent to obtain gamma-aminopropanol. The method has the advantages that the yield is high, the purity of the prepared gamma-aminopropanol is high, the operation is simple and convenient, the raw materials are cheap and easy to obtain, the method is safe and controllable, the method is green and environment-friendly, the cost is better, the method is suitable for industrial production and the like, and the quality, the yield, the effectiveness and the safety of the product prepared from the gamma-aminopropanol are remarkably improved.
Preparation method of 3-aminopropanol
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Paragraph 0064; 0066, (2020/05/05)
The invention relates to a preparation method of 3-aminopropanol, wherein the preparation method comprises the following steps: (1) carrying out a reaction on acrylonitrile with benzyl alcohol under the catalysis of a base catalyst, and separating the obtained reaction solution to obtain 3-benzyloxypropionitrile; and (2) in a liquid-phase reaction system in the presence of a hydrogenation catalyst, carrying out a hydrogenation reaction on the 3-benzyloxypropionitrile, separating the obtained reaction liquid to obtain 3-aminopropanol, and recycling the obtained by-product toluene as an extractant in the step (1).
Catalyst for producing 3-aminopropanol by hydrogenating 3-hydroxypropionitrile and preparation method thereof
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Paragraph 0110; 0111; 0116-0118; 0126, (2020/06/09)
The invention discloses a catalyst for producing 3-aminopropanol by hydrogenating 3-hydroxypropionitrile. The catalyst is characterized in that the catalyst comprises an active component and a carrier, wherein the active component comprises active metal elements; the active metal elements comprise M and Re; M is selected from at least one of Ni, Co and Cu; M accounts for 5.0-50.0% of the weight ofthe catalyst; Re accounts for 0.1-15.0% of the weight of the catalyst; and the carrier is selected from at least one of inorganic porous materials. The catalyst has high catalytic activity and selectivity.
Preparation method of 3-aminopropanol
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Paragraph 0020-0089, (2019/03/28)
The invention provides a preparation method of 3-aminopropanol, which is high in conversion rate. The invention adopts the following technical scheme: adding 3-hydroxypropionitrile into a reactor witha nickel catalyst and silver nitrate, and then adding an amine reagent under nitrogen; then introducing hydrogen into the reactor, stirring for reducing reaction, and performing precipitation and distillation to prepare the 3-aminopropanol. The raw materials are high in utilization rate; the separation process is simple and clear; the energy consumption is low; the production cost of a product islow; and the solvent and the catalyst can be recycled for use.
Organocatalytic Decarboxylation of Amino Acids as a Route to Bio-based Amines and Amides
Claes, Laurens,Janssen, Michiel,De Vos, Dirk E.
, p. 4297 - 4306 (2019/08/26)
Amino acids obtained by fermentation or recovered from protein waste hydrolysates represent an excellent renewable resource for the production of bio-based chemicals. In an attempt to recycle both carbon and nitrogen, we report here on a chemocatalytic, metal-free approach for decarboxylation of amino acids, thereby providing a direct access to primary amines. In the presence of a carbonyl compound the amino acid is temporarily trapped into a Schiff base, from which the elimination of CO2 may proceed more easily. After evaluating different types of aldehydes and ketones on their activity at low catalyst loadings (≤5 mol%), isophorone was identified as powerful organocatalyst under mild conditions. After optimisation many amino acids with a neutral side chain were converted in 28–99 % yield in 2-propanol at 150 °C. When the reaction is performed in DMF, the amine is susceptible to N-formylation. This consecutive reaction is catalysed by the acidity of the amino acid reactant itself. In this way, many amino acids were efficiently transformed to the corresponding formamides in a one-pot catalytic system.
Oxidative Deprotection of p-Methoxybenzyl Ethers via Metal-Free Photoredox Catalysis
Ahn, Deok Kyun,Kang, Young Woo,Woo, Sang Kook
, p. 3612 - 3623 (2019/03/11)
An efficient and greener deprotection method for p-methoxybenzyl (PMB) ethers using a metal-free visible light photoredox catalyst and air and ammonium persulfate as the terminal oxidants is presented. Various functional groups and protecting groups were tolerated in the developed method to achieve good to excellent yields in short reaction times. Significantly, the developed method was compatible with PMB ethers derived from primary, secondary, and tertiary alcohols and a gram-scale reaction. Mechanistic studies support a proposed reaction mechanism that involves single electron oxidation of the PMB ether.
METHOD FOR PRODUCING CIS- AND TRANS-ENRICHED MDACH
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, (2017/09/23)
A process for preparing trans-enriched MDACH, including: distilling an MDACH starting mixture in the presence of an auxiliary, which is an organic compound having a molar mass of 62 to 500 g/mol, a boiling point at least 5° C. above the boiling point of cis,cis-2,6-diamino-1-methylcyclohexane, and 2 to 4 functional groups, each of which is independently an alcohol group or a primary, secondary or tertiary amino group. The MDACH starting mixture includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, based on the total amount of MDACH present in the MDACH starting mixture. The MDACH starting mixture includes both trans and cis isomers. Trans-enriched MDACH includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, where the proportion of trans isomers in the mixture is higher than the proportion of trans isomers in the MDACH starting mixture.
The invention relates to a propylene glycol and liquid ammonia as raw materials for preparing propylene diamine method and apparatus thereof
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Paragraph 0080-0081; 0090, (2017/08/31)
The invention relates to a method for preparing propane diamine by taking propylene glycol and liquid ammonia as raw materials. Propylene glycol and liquid ammonia are mixed in a certain ratio and are pumped into a reactor by virtue of a pump, and reaction is carried out in presence of a catalyst and hydrogen. The method for preparing the propane diamine by taking the propylene glycol and liquid ammonia as the raw materials has the advantages that a novel catalyst is adopted, catalytic performance is excellent, and long-time operation can be easily carried out; propylene glycol is subjected to hydroamination for producing a propane diamine product at lower reaction pressure, and reaction conditions are adjusted and changed, so that composition of the product can be flexibly adjusted and changed, selectivity of a target product is improved, a reaction process is simple, one-time investment of a production unit and production cost are reduced, a reaction product and a catalyst can be simply separated, and large-scale continuous industrial production can be easily realized.
HIV INTEGRASE INHIBITORS
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, (2015/09/22)
The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
