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Rapacuronium is a steroidal derivative belonging to the same class as vecuronium bromide. It is an aminosteroidal nondepolarizing neuromuscular blocking agent with a rapid onset and a short duration of action. Rapacuronium bromide is used as an adjunct to general anesthesia during surgical procedures, offering a relatively low potency compared to other agents.

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  • 156137-99-4 Structure
  • Basic information

    1. Product Name: Rapacuronium
    2. Synonyms: Rapacuronium;Org 9487;Raplon
    3. CAS NO:156137-99-4
    4. Molecular Formula: C37H61N2O4.Br
    5. Molecular Weight: 677.803
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 156137-99-4.mol
  • Chemical Properties

    1. Melting Point: 184°
    2. Boiling Point: °Cat760mmHg
    3. Flash Point: °C
    4. Appearance: /
    5. Density: g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Rapacuronium(CAS DataBase Reference)
    10. NIST Chemistry Reference: Rapacuronium(156137-99-4)
    11. EPA Substance Registry System: Rapacuronium(156137-99-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 156137-99-4(Hazardous Substances Data)

156137-99-4 Usage

Uses

Used in Anesthesia:
Rapacuronium is used as an adjunct to general anesthesia for surgical procedures. It is particularly useful due to its rapid onset and short duration of action, making it a suitable alternative to the depolarizing agent succinylcholine with a very short duration of action.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Rapacuronium is used as a nondepolarizing neuromuscular blocking drug. Its synthesis involves a three-step process starting from the 3-hydroxy-androstan-17-one analog and is quaternized with allyl bromide. Rapacuronium's relatively low potency (ED90 = 1.15 mg/kg) makes it a valuable compound for developing anesthesia medications.
Brand Name:
Rapacuronium bromide is marketed under the brand name Raplon.

Check Digit Verification of cas no

The CAS Registry Mumber 156137-99-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,1,3 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 156137-99:
(8*1)+(7*5)+(6*6)+(5*1)+(4*3)+(3*7)+(2*9)+(1*9)=144
144 % 10 = 4
So 156137-99-4 is a valid CAS Registry Number.
InChI:InChI=1/C37H61N2O4.BrH/c1-6-20-39(21-12-9-13-22-39)32-24-30-28-15-14-27-23-33(42-26(3)40)31(38-18-10-8-11-19-38)25-37(27,5)29(28)16-17-36(30,4)35(32)43-34(41)7-2;/h6,27-33,35H,1,7-25H2,2-5H3;1H/q+1;/p-1/t27-,28+,29-,30-,31-,32-,33-,35-,36-,37-;/m0./s1

156137-99-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetyloxy-10,13-dimethyl-2-piperidin-1-yl-16-(1-prop-2-enylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate,bromide

1.2 Other means of identification

Product number -
Other names Rapacuronium bromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:156137-99-4 SDS

156137-99-4Upstream product

156137-99-4Downstream Products

156137-99-4Relevant articles and documents

Monoquaternary 2,16-bispiperidinylandrostane derivatives

-

, (2008/06/13)

Monoquaternary 2,16-bispiperidinylandrostane neuromuscular blocking derivatives having the formula: STR1 wherein R1 is ethyl; R2 is methyl or allyl; and X- is a pharmaceutically acceptable anion; or pharmaceutically acceptable salts thereof.

Novel 2β,16β-diamino-androstanes

-

, (2008/06/13)

2β,16β-diamino-3α,17α-oxygenated androstanes having one quaternized group, process for the preparation of these compounds and pharmaceutical compositions comprising such compounds as the active ingredient. The aforementioned compounds are favourable neuro

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