- Useful synthesis of 2,3,6-polythiazolesubstituted pyridine skeleton [Fragment A-C] of peptide antibiotic, micrococcin P
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Practical synthesis of 2,3,6-trithiazolesubstituted pyridine skeleton [Fragment A-C] of peptide antibiotic micrococcin P was achieved from 3-cyano-6-dimethoxymethyl-2-pyridone in twelve steps.
- Okumura, Kazuo,Shigekuni, Masashi,Nakamura, Yutaka,Shin, Chung-Gi
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p. 1025 - 1026
(2007/10/03)
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- An efficient synthesis of 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid and some carbonyl derivatives of it and its 6-acetyl homologue
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Starting with 1,1-dimethoxy-2-propanone (1), 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid (5a) has been prepared in large quantities by a highly efficient, 4-step synthesis. This compound, along with its one carbon homologue, 6-acetyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid (5b) has been reacted with several carbonyl derivative forming reagents to provide a series of side chains for β-lactams. Among these carbonyl derivatives are styrylamides which were prepared from Wittig and Horner-Emmons reagents. The preparation of the phosphonium salts and phosphonate esters is also described.
- Sanchez,Mich,Huang
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p. 297 - 303
(2007/10/02)
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