156459-19-7

Upstream product

• 107-91-5 cyanoacetic acid amide 
• 6342-56-9 Pyruvic aldehyde dimethyl acetal 

Downstream Products

• 156459-21-1 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid 
• 348128-80-3 2-(1-tert-butoxycarbonylamino-ethyl)-6-{4-[1-tert-butoxycarbonyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylthiocarbamoyl]-thiazol-2-yl}-nicotinic acid benzyl ester 
• 348128-79-0 2-(1-tert-butoxycarbonylamino-ethyl)-6-{4-[1-tert-butoxycarbonyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-thiazol-2-yl}-nicotinic acid benzyl ester 
• 348128-73-4 phenacyl (RS)-2-[2-(1-t-butoxycarbonylaminoethyl)-3-(t-butyldiphenylsiloxymethyl)pyridin-6-yl]-1,3-thiazole-4-carboxylate 
• 348128-81-4 2-(1-tert-butoxycarbonylamino-ethyl)-6-[4-(1-tert-butoxycarbonyl-2-hydroxy-ethylthiocarbamoyl)-thiazol-2-yl]-nicotinic acid benzyl ester 
• 348128-82-5 2-(1-tert-butoxycarbonylamino-ethyl)-6-[4-(1-tert-butoxycarbonyl-2-hydroxy-ethylthiocarbamoyl)-thiazol-2-yl]-nicotinic acid benzyl ester 
• 348128-83-6 t-butyl (4S)-2-(2-{3-benzyloxycarbonyl-2-[(1R)-1-t-butoxycarbonylaminoethyl]pyridin-6-yl}-1,3-thiazol-4-yl)-4,5-dihydro-1,3-thiazole-4-carboxylate 
• 348128-85-8 t-butyl (4S)-2-(2-{3-benzyloxycarbonyl-2-[(1S)-1-t-butoxycarbonylaminoethyl]pyridin-6-yl}-1,3-thiazol-4-yl)-4,5-dihydro-1,3-thiazole-4-carboxylate 
• 348128-89-2 (R)-2'-[5-Benzyloxycarbonyl-6-((R)-1-tert-butoxycarbonylamino-ethyl)-pyridin-2-yl]-4,5-dihydro-[2,4']bithiazolyl-4-carboxylic acid 
• 348128-72-3 (RS)-2-[2-(1-t-butoxycarbonylaminoethyl)-3-(t-butyldiphenylsiloxymethyl)pyridin-6-yl]-1,3-thiazole-4-carboxylic acid 
• 348128-71-2 methyl (RS)-2-[2-(1-t-butoxycarbonylaminoethyl)-3-(t-butyldiphenylsiloxymethyl)pyridin-6-yl]-1,3-thiazole-4-carboxylate 
• 348128-74-5 phenacyl (RS)-2-[2-(1-t-butoxycarbonylaminoethyl)-3-(hydroxymethyl)pyridin-6-yl]-1,3-thiazole-4-carboxylate 
• 348128-69-8 (RS)-2-(1-t-butoxycarbonylaminoethyl)-3-(t-butyldiphenylsiloxymethyl)-6-(dimethoxymethyl)pyridine 
• 348128-75-6 phenacyl (RS)-2-(1H-2-t-butoxycarbonyl-1-oxo-2,3-dihydropyrrolo[3,4-b]pyridin-5-yl)-1,3-thiazole-4-carboxylate 

Relevant academic research and scientific papers

Useful synthesis of 2,3,6-polythiazolesubstituted pyridine skeleton [Fragment A-C] of peptide antibiotic, micrococcin P

Practical synthesis of 2,3,6-trithiazolesubstituted pyridine skeleton [Fragment A-C] of peptide antibiotic micrococcin P was achieved from 3-cyano-6-dimethoxymethyl-2-pyridone in twelve steps.

An efficient synthesis of 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid and some carbonyl derivatives of it and its 6-acetyl homologue

Starting with 1,1-dimethoxy-2-propanone (1), 6-formyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid (5a) has been prepared in large quantities by a highly efficient, 4-step synthesis. This compound, along with its one carbon homologue, 6-acetyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid (5b) has been reacted with several carbonyl derivative forming reagents to provide a series of side chains for β-lactams. Among these carbonyl derivatives are styrylamides which were prepared from Wittig and Horner-Emmons reagents. The preparation of the phosphonium salts and phosphonate esters is also described.