- Wavelength-Orthogonal Photocleavable Monochromophoric Linker for Sequential Release of Two Different Substrates
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A wavelength-orthogonal photocleavable monochromophoric linker was developed that is based on a 3-acetyl-9-ethyl-6-methylcarbazole (AEMC) moiety substituted at both the phenacyl and benzylic positions with different carboxylic acids. The different carboxylic acids were released sequentially upon irradiation with light of λ ≥ 365 nm and λ ≥ 290 nm, respectively.
- Venkatesh, Yarra,Chaudhuri, Amrita,Mondal, Saugat,Shah, Sk. Sheriff,Singh, N. D. Pradeep
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Read Online
- New broom fiber (Spartium junceum L.) derivatives: Preparation and characterization
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In the past decade interest in biopolymers has increased. Attempts were made to prepare new composite systems from biopolymers by binding different synthetic polymers to a biopolymer backbone. This paper reports the synthesis and characterization of deriv
- Cassano, Roberta,Trombino, Sonia,Bloise, Ermelinda,Muzzalupo, Rita,Iemma, Francesca,Chidichimo, Giuseppe,Picci, Nevio
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Read Online
- Photo-cross-linking and de-cross-linking of modified polystyrenes having degradable linkages
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Modified polystyrenes having both epoxy moieties and tertiary ester linkages, tertiary ether linkages, or carbonate linkages were synthesized. The polymer films containing a photoacid generator were photo-cross-linkable. The cross-linked polymer films bec
- Okamura, Haruyuki,Yamauchi, Etsushi,Shirai, Masamitsu
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Read Online
- Ni-Catalyzed Direct Carboxylation of Aryl C?H Bonds in Benzamides with CO2
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The direct carboxylation of inert aryl C?H bond catalyzed by abundant and cheap nickel is still facing challenge. Herein, we report the Ni-catalyzed direct carboxylation of aryl C?H bonds in benzamides under 1 atm of CO2 to afford various methyl carboxylates or phthalimides, dealing with different post-processing. The reaction displays excellent functional group tolerance and affords moderate to high carboxylation yields under mild conditions. Detail mechanistic studies suggest that a Ni(0)?Ni(II)?Ni(I) catalytic cycle may be involved in this reaction. (Figure presented.).
- Pei, Chunzhe,Zong, Jiarui,Li, Bin,Wang, Baiquan
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supporting information
p. 493 - 499
(2021/12/08)
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- PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation
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A PCl3-mediated conversion of tert-butyl esters into esters and amides in one-pot under air is developed. This novel protocol is highlighted by the synthesis of skeletons of bioactive molecules and gram-scale reactions. Mechanistic studies revealed that this transformation involves the formation of an acid chloride in situ, which is followed by reactions with alcohols or amines to afford the desired products.
- Wu, Xiaofang,Zhou, Lei,Li, Fangshao,Xiao, Jing
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p. 491 - 497
(2021/01/20)
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- Regioselective Three-Component Synthesis of Vicinal Diamines via 1,2-Diamination of Styrenes
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The vicinal diamine motif plays a significant role in natural products, drug design, and organic synthesis, and development of synthetic methods for the synthesis of diamines is a long-standing interest. Herein, we report a regioselective intermolecular three-component vicinal diamination of styrenes with acetonitrile and azodicarboxylates. The diamination products can be produced in moderate to excellent yields via the Ritter reaction. Synthetic applications and theoretical studies of this reaction have been conducted.
- Cao, Jie,Lv, Daqi,Yu, Fei,Chiou, Mong-Feng,Li, Yajun,Bao, Hongli
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supporting information
p. 3184 - 3189
(2021/05/05)
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- Direct Synthesis of Enamides via Electrophilic Activation of Amides
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A novel, one-step N-dehydrogenation of amides to enamides is reported. This reaction employs the unlikely combination of LiHMDS and triflic anhydride, which serves as both the electrophilic activator and the oxidant, and is characterized by its simple setup and broad substrate scope. The synthetic utility of the formed enamides was readily demonstrated in a range of downstream transformations.
- Berger, Martin,Kaiser, Daniel,Maulide, Nuno,Spie?, Philipp
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supporting information
p. 10524 - 10529
(2021/07/28)
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- Electrodimerization ofN-Alkoxyamides for the Synthesis of Hydrazines
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An efficient and valuable N-N dimerization reaction ofN-alkoxyamides is reported under undivided electrolytic conditions. This electrochemical strategy provides a powerful way to access a wide range of advanced, highly functionalized hydrazines. Remarkably, anN-centered radical generated from the cleavage of the N-H bond under electrolytic conditions plays a crucial role in this transformation. Furthermore, variousN-alkoxyamides bearing different substituents are suitable in this transformation, furnishing the corresponding hydrazines in up to 92% yield.
- Nasier, Abudulajiang,Chang, Xihao,Guo, Chang
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p. 16068 - 16076
(2021/09/18)
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- Synthesis of N-trifluoromethyl amides from carboxylic acids
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Found in biomolecules, pharmaceuticals, and agrochemicals, amide-containing molecules are ubiquitous in nature, and their derivatization represents a significant methodological goal in fluorine chemistry. Trifluoromethyl amides have emerged as important functional groups frequently found in pharmaceutical compounds. To date, there is no strategy for synthesizing N-trifluoromethyl amides from abundant organic carboxylic acid derivatives, which are ideal starting materials in amide synthesis. Here, we report the synthesis of N-trifluoromethyl amides from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature. Through this strategy, isothiocyanates are desulfurized with AgF, and then the formed derivative is acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method shows broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners, and should find application in the modification of advanced intermediates.
- Flavell, Robert R.,Liu, Jianbo,Parker, Matthew F. L.,Toste, F. Dean,Wang, Sinan,Wilson, David M.
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supporting information
p. 2245 - 2255
(2021/08/12)
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- Palladium-Catalyzed Chlorocarbonylation of Aryl (Pseudo)Halides Through In Situ Generation of Carbon Monoxide
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An efficient palladium-catalyzed chlorocarbonylation of aryl (pseudo)halides that gives access to a wide range of carboxylic acid derivatives has been developed. The use of butyryl chloride as a combined CO and Cl source eludes the need for toxic, gaseous carbon monoxide, thus facilitating the synthesis of high-value products from readily available aryl (pseudo)halides. The combination of palladium(0), Xantphos, and an amine base is essential to promote this broadly applicable catalytic reaction. Overall, this reaction provides access to a great variety of carbonyl-containing products through in situ transformation of the generated aroyl chloride. Combined experimental and computational studies support a reaction mechanism involving in situ generation of CO.
- Bismuto, Alessandro,Boehm, Philip,Morandi, Bill,Roediger, Sven
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supporting information
p. 17887 - 17896
(2020/08/19)
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- A practical chlorination of tert-butyl esters with PCl3 generating acid chlorides
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For the first time, using PCl3, a range of tert-butyl esters is chlorinated successfully, allowing access of both aromatic acid chlorides and aliphatic acid chlorides in good yields. The method features simple reaction conditions and wide substrate scope. Various tert-butyl esters including aryl esters, alkenyl esters, and alkyl esters were tolerated well in the reaction. A plausible mechanism is proposed.
- Wu, Xiaofang,Zhou, Lei,Yang, Ruoqi,Guo, Fengzhe,Tang, Zi-Long,Xiao, Jing
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p. 301 - 304
(2020/01/29)
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- Palladium-Catalyzed Mizoroki-Heck Reaction of Nitroarenes and Styrene Derivatives
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We have developed a Mizoroki-Heck reaction of nitroarenes with alkenes under palladium catalysis. The use of a Pd/BrettPhos catalyst promoted the alkenylation, whereas other catalysts led to a decrease in the product yield. In addition to nitroarenes, nitroheteroarenes were also applicable to the present reaction. The combination of a nucleophilic aromatic substitution (SNAr) with the denitrative alkenylation produced a multifunctionalized arene in a one-pot operation.
- Okita, Toshimasa,Asahara, Kitty K.,Muto, Kei,Yamaguchi, Junichiro
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supporting information
p. 3205 - 3208
(2020/04/10)
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- Cu-Catalyzed C-H Alkenylation of Benzoic Acid and Acrylic Acid Derivatives with Vinyl Boronates
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An efficient Cu-catalyzed C-H alkenylation with acyclic and cyclic vinyl boronates was realized for the first time under mild conditions. The scope of the vinyl borons and the compatibility with functional groups including heterocycles are superior than Pd-catalyzed C-H coupling with vinyl borons, providing a reliable access to multisubstituted alkenes and dienes. Subsequent hydrogenation of the product from the internal vinyl borons will lead to installation of secondary alkyls.
- Li, Jian-Jun,Wang, Cheng-Gang,Yu, Jin-Feng,Wang, Peng,Wang, Peng,Yu, Jin-Quan
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supporting information
p. 4692 - 4696
(2020/06/25)
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- Modular Tuning of Electrophilic Reactivity of Iridium Nitrenoids for the Intermolecular Selective α-Amidation of β-Keto Esters
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We report herein an Ir-catalyzed intermolecular amino group transfer to β-keto esters (amides) to access α-aminocarbonyl products with excellent chemoselectivity. The key strategy was to engineer electrophilicity of the putative Ir-nitrenoids by tuning electronic property of the κ2-N,O chelating ligands, thus facilitating nucleophilic addition of enol π-bonds of 1,3-dicarbonyl substrates.
- Lee, Minhan,Jung, Hoimin,Kim, Dongwook,Park, Jung-Woo,Chang, Sukbok
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supporting information
p. 11999 - 12004
(2020/08/06)
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- Nickel-catalyzed three-component reductive alkylacylation of electron-deficient activated alkenes
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Herein, we present a nickel-catalyzed three-component reductive alkylacylation of electron-deficient activated alkenes with tertiary alkyl bromides and acid anhydrides. This method enables the efficient preparation of a variety of ketones with broad substrate scope and high functionality tolerance starting from simple precursors. On the basis of the preliminary mechanistic investigations, a catalytic cycle involving the synergistic interaction of nickel, zinc, and MgCl2 is proposed as the major reaction pathway.
- Wang, Lin,Wang, Chuan
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supporting information
p. 8829 - 8835
(2020/11/13)
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- Preparation method of aromatic acyl chloride
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The invention discloses a preparation method of aromatic acyl chloride. An aromatic acyl chloride compound is prepared through a reaction of aryl carboxylic acid and phosphorus trichloride. The preparation method of the aromatic acyl chloride has the advantages that the phosphorus trichloride is taken as a chloride reagent, the corresponding acyl chloride is synthesized from the aryl carboxylic acid, so that the production cost is low, the operation is simple, a by-product is low in toxicity, the environmental friendliness is achieved, the yield is high, and the method is conductive to industrial production.
- -
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Paragraph 0063-0066
(2019/07/11)
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- Cu-Mediated C-H Thioetherification of Arenes at Room Temperature
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Cu-mediated C-H thioetherification of arenes with ethylene sulfide has been developed using a readily removable directing group. The reaction proceeded at room temperature, and a variety of sensitive functional groups including chloro, bromo, and vinyl were well tolerated. The thiolated products could be converted to the seven-membered benzoxathiepinones derivatives by a sequence of hydrolysis-lactonization reactions.
- Wang, Xing,Yi, Xing,Xu, Hui,Dai, Hui-Xiong
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supporting information
p. 5981 - 5985
(2019/08/26)
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- RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, POLYMERIC COMPOUND, AND COMPOUND
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A resist composition including a resin component which exhibits changed solubility in a developing solution under action of acid, the resin component including a structural unit represented by general formula (a0) shown below in which Vax0 repr
- -
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Paragraph 0683-0685
(2020/01/04)
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- Steric hindrance effect on the thermo- and photo-responsive properties of pyrene-based polymers
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In this work, the influence of the steric hindrance effect between a polymeric backbone and the side groups on the lower critical solution temperature (LCST)-type behavior and photodegradation behavior, respectively, has been carefully studied. A series o
- Liao, Junqiu,Liu, Shenglan,Yuan, Yongjie,Zhang, Hailiang
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p. 5698 - 5708
(2018/04/23)
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- Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon
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Herein, rhodium(III)-catalyzed C-H activation/subsequent [4 + 1] cyclization reactions between benzamides and propargyl alcohols are reported in which propargyl alcohols serve as unusual one-carbon units. This title transformation led to a series of isoin
- Wu, Xiaowei,Wang, Bao,Zhou, Yu,Liu, Hong
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supporting information
p. 1294 - 1297
(2017/03/23)
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- A General Method for Aminoquinoline-Directed, Copper-Catalyzed sp2 C-H Bond Amination
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An operationally simple and general method for copper-catalyzed, aminoquinoline-assisted amination of β-C(sp2)-H bonds of benzoic acid derivatives is reported. The reaction employs Cu(OAc)2 or (CuOH)2CO3 catalysts, an amine coupling partner, and oxygen from air as a terminal oxidant. Exceptionally high generality with respect to amine coupling partners is observed. Specifically, primary and secondary aliphatic and aromatic amines, heterocycles, such as indoles, pyrazole, and carbazole, sulfonamides, as well as electron-deficient aromatic and heteroaromatic amines are competent coupling components.
- Roane, James,Daugulis, Olafs
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supporting information
p. 4601 - 4607
(2016/05/09)
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- Polystyrene supported benzoylthiourea—pyrrolidine organocatalyst for the enantioselective Michael addition
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Herein the preparation of a swellable pearl-like copolymer of styrene with anchored (S)-1-benzoyl-3-(pyrrolidine-2-ylmethyl)thiourea (20–600?μm) and its application as a recyclable organocatalyst for the Michael addition of ketones to functionalized β-nit
- Androvi?, Ladislav,Drabina, Pavel,Svobodová, Markéta,Sedlák, Milo?
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p. 782 - 787
(2016/07/29)
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- Rhodium-Catalyzed Hydrocarboxylation of Olefins with Carbon Dioxide
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The catalytic hydrocarboxylation of styrenes derivatives and α,β-unsaturated carbonyl compounds with CO2(101.3 kPa) in the presence of an air-stable rhodium catalyst was explored. The combination of [RhCl(cod)]2(cod = cyclooctadiene) as a catalyst and diethylzinc as a hydride source allowed for effective hydrocarboxylation and provided the corresponding α-aryl carboxylic acids in moderate to excellent yields. In this catalytic process with carbon dioxide, intervention of the RhI–H species, which could be generated from the RhIcatalyst and diethylzinc, was clarified. Significantly, the catalytic asymmetric hydrocarboxylation of α,β-unsaturated esters with carbon dioxide was also performed by employing a cationic rhodium complex possessing (S)-(–)-4,4′-bi-1,3-benzodioxole-5,5′-diylbis(diphenylphosphine) [(S)-SEGPHOS] as a chiral diphosphine ligand. A plausible model for asymmetric induction was proposed by determination of the absolute configuration of the product.
- Kawashima, Shingo,Aikawa, Kohsuke,Mikami, Koichi
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supporting information
p. 3166 - 3170
(2016/07/19)
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- Cu(II)-catalyzed coupling of aromatic C-H bonds with malonates
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A new Cu(II)-catalyzed oxidative coupling of arenes with malonates has been developed using an amide-oxazoline directing group. The reaction proceeds via C(sp2)-H activation and malonate coupling, followed by intramolecular oxidative N-C bond formation. A variety of arenes bearing different substituents are shown to be compatible with this reaction.
- Wang, Hong-Li,Shang, Ming,Sun, Shang-Zheng,Zhou, Zeng-Le,Laforteza, Brian N.,Dai, Hui-Xiong,Yu, Jin-Quan
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supporting information
p. 1228 - 1231
(2015/03/14)
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- Pesticidal compositions and processes related thereto
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This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
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Page/Page column 48
(2016/01/09)
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- A dispersion of the water insoluble material, its manufacturing method, and using the same liquid, Inkset, printed matter, image forming method and image forming device
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A water-insoluble colorant dispersion, containing water; a polymer having at least one repeating unit selected from the group of repeating units represented by the following formula (1) or (2); and water-insoluble colorant particles, each of the particles
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Paragraph 0144; 0145
(2016/10/10)
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- PH-mediated catch and release of charged molecules with porous hollow nanocapsules
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Here, we show that the charge of the nanopores in the nanometer-thin shells of hollow porous nanocapsules can regulate the transport of charged molecules. By changing the pH of external aqueous solution, we can entrap charged molecules in nanocapsules and
- Dergunov, Sergey A.,Durbin, Jeffrey,Pattanaik, Sambit,Pinkhassik, Eugene
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supporting information
p. 2212 - 2215
(2014/03/21)
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- Cis-specific hydrofluorination of alkenylarenes under palladium catalysis through an ionic pathway
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This paper describes the hydrofluorination of alkenes through sequential H- and F+ addition under palladium catalysis. The reaction is cis specific, thus providing access to benzylic fluorides. The mechanism of this reaction involves an ionic pathway and is distinct from known hydrofluorinations involving radical intermediates. The first catalytic enantioselective hydrofluorination is also disclosed. See attached PdF: A series of benzylic fluorides was prepared by hydrofluorination which proceeds through a PdII/IV catalytic manifold. The method is mechanistically distinct from previously reported radical hydrofluorination, and is characterized by its clean regioselectivity and unique cis stereospecificity. The first example of enantioselective net HF addition onto 2-vinylnaphthalene is also disclosed.
- Emer, Enrico,Pfeifer, Lukas,Brown, John M.,Gouverneur, Veronique
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supporting information
p. 4181 - 4185
(2014/05/06)
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- PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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This document discloses molecules having the following formula ("Formula One"): and processes associated therewith.
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Page/Page column 49
(2014/07/08)
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- PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
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Paragraph 0209
(2014/06/25)
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- N-heterocyclic carbene catalyzed umpolung of styrenes: Mechanistic elucidation and selective tail-to-tail dimerization
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The reaction between N-heterocyclic carbenes (NHCs) and styrenes yields alkyl-substituted azolium salts, which are able to form nucleophilic deoxy Breslow intermediates by simple deprotonation. This hitherto unknown reaction of NHCs represents a new way to generate deoxy Breslow intermediates and paves the way for the selective NHC-catalyzed tail-to-tail homodimerization of styrenes. This reaction significantly broadens the scope of the Michael umpolung and provides a new method to generate 1,4-diaryl compounds.
- Schedler, Michael,Wurz, Nathalie E.,Daniliuc, Constantin G.,Glorius, Frank
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supporting information
p. 3134 - 3137
(2014/06/23)
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- PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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This document discloses molecules having the following formula ("Formula One") and processes associated therewith.
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Page/Page column 50
(2014/07/08)
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- Cu(II)-mediated ortho C-H alkynylation of (hetero)arenes with terminal alkynes
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Cu(II)-promoted ortho alkynylation of arenes and heteroarenes with terminal alkynes has been developed to prepare aryl alkynes. A variety of arenes and terminal alkynes bearing different substituents are compatible with this reaction, thus providing an alternative disconnection to Sonogashira coupling.
- Shang, Ming,Wang, Hong-Li,Sun, Shang-Zheng,Dai, Hui-Xiong,Yu, Jin-Quan
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supporting information
p. 11590 - 11593
(2014/10/15)
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- Cu(II)-mediated C-H amidation and amination of arenes: Exceptional compatibility with heterocycles
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A Cu(OAc)2-mediated C-H amidation and amination of arenes and heteroarenes has been developed using a readily removable directing group. A wide range of sulfonamides, amides, and anilines function as amine donors in this reaction. Heterocycles present in both reactants are tolerated, making this a broadly applicable method for the synthesis of a family of inhibitors including 2-benzamidobenzoic acids and N-phenylaminobenzoates.
- Shang, Ming,Sun, Shang-Zheng,Dai, Hui-Xiong,Yu, Jin-Quan
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supporting information
p. 3354 - 3357
(2014/03/21)
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- Ultrabright fluorescent polymeric nanoparticles made from a new family of BODIPY monomers
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Four novel BODIPY derivatives (π-) functionalized by different polymerizable groups, styrene (S), phenyl acrylate (PhA), ethyl methacrylate (EtMA) and ethyl acrylate (EtA) have been synthesized. Following a formerly established one-pot RAFT miniemulsion p
- Grazon, Chloe,Rieger, Jutta,Meallet-Renault, Rachel,Charleux, Bernadetfte,Clavier, Gilles
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supporting information
p. 5167 - 5176
(2013/07/26)
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- A synthetic amino acid residue containing a new oligopeptide-based photosensitive fluorescent organogel
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A synthetic amino acid (with a stilbene residue in the main chain) containing a tripeptide-based organogelator has been discovered. This peptide-based synthetic molecule 1 self-assembles in various organic solvents to form an organogel. The gel has been thoroughly characterized by using various microscopic techniques including field-emission scanning electron microscopy (FESEM), atomic force microscopy (AFM), X-ray diffraction (XRD), UV-visible and fluorescence spectroscopy, and rheology. Morphological investigations using FESEM and AFM show a nanofibrillar network structure. Interestingly, the organogel is photoresponsive and a gel-sol transition occurred by irradiating the gel with UV light of 365 nm for 2 h as shown by the UV and fluorescence study. This photoresponsive fluorescent gel holds promise for new peptide-based soft materials with interesting applications. Copyright
- Maiti, Dibakar Kumar,Banerjee, Arindam
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supporting information
p. 113 - 120
(2013/02/26)
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- Synthesis and characterization of hydroxy-bisphosphonate micrometer-sized particles by dispersion polymerization of a new styrylbisphosphonate monomer
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Bisphosphonates (BPs) are nonhydrolyzable pyrophosphate (P-O-P) analogs possessing two phosphonate groups linked to a single carbon (P-C-P). The hydroxy-bisphosphonates (hydroxyBPs) are obtained when the hydroxy group is also linked to this bridging carbo
- Chen, Ravit,Goldshtein, Jenny,Margel, Shlomo
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p. 2199 - 2207
(2013/06/05)
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- A peptide based two component white light emitting system
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A peptide based two component white light emitting system has been designed and developed on the basis of a co-assembly of a PDI containing peptide system as an acceptor and a stilbene containing peptide system as a donor in organic solvents.
- Maiti, Dibakar Kumar,Banerjee, Arindam
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supporting information
p. 6909 - 6911
(2013/07/26)
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- BISPHOSPHONATES VINYLIC MONOMERS AND POLYMERS AND USES THEREOF
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The present invention provides novel bisphosphonates vinylic monomers, polymers and particles that have utility as biologically active molecule (such as drugs) carriers, medical device coatings and for imaging/radiology applications, especially in bone and dental applications. The invention also provides methods of synthesizing the monomers, polymerizing the polymers, and assembling the particles of the invention.
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Paragraph 0154
(2014/01/07)
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- Precision polyelectrolytes
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Charged macromolecules with controlled microstructures were prepared. Well-defined non-ionic precursors were first synthesized by sequence-controlled radical polymerization of tert-butyl 4-vinyl benzoate with various N-substituted maleimides. Afterwards, these macromolecules were hydrolyzed into polyanions.
- Srichan, Sansanee,Oswald, Laurence,Zamfir, Mirela,Lutz, Jean-Franois
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supporting information; scheme or table
p. 1517 - 1519
(2012/03/26)
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- PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
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Page/Page column 26
(2013/02/28)
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- One-pot synthesis of cyclic triamides with a triangular cavity from trans-stilbene and diphenylacetylene monomers
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(Chemical Equation Presented) Base-promoted self-condensation reactions of trans-stilbene and diphenylacetylene monomers bearing 4-alkylamino and 4′-methoxycarbonyl groups were investigated. Reactions of N-propyl monomers under pseudohigh-dilution conditions (a THF solution of monomer was added dropwise to a THF solution of LiHMDS) afforded the corresponding cyclic triamides in good yields. X-ray crystallographic analysis showed that these cyclic triamides possessed an almost equilateral triangle structure with a cavity surrounded by tilted benzene rings.
- Yokoyama, Akihiro,Maruyama, Takurou,Tagami, Kei,Masu, Hyuma,Katagiri, Kosuke,Azumaya, Isao,Yokozawa, Tsutomu
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supporting information; experimental part
p. 3207 - 3210
(2009/05/11)
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- Near-infrared electrochromic and electroluminescent polymers containing pendant ruthenium complex groups
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A series of near-infrared (NIR) electrochromic and electroluminescent polymers containing the pendant dinuclear ruthenium complexes were synthesized and characterized. All the polymers are near-infrared (NIR) electrochromic, displaying an intense absorption centered at 1600 nm upon oxidation to the mixed-valence state. Single-layer diode devices comprising a layer of the complex polymers sandwiched between the ITO and Au electrodes emitted the NIR light centered at 790 nm at ambient temperature.
- Wang, Sheng,Li, Xianzhen,Xun, Shidi,Wan, Xinhua,Wang, Zhi Yuan
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p. 7502 - 7507
(2007/10/03)
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- Multiresponsive photopatterning organic-inorganic polymer hybrids using a caged photoluminescence compound
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The caged photoluminescence compound 2-(2′-benzoylphenyl)benzoxazole (BzPO) modified with poly(N,N-dimethylacrylamide) was synthesized. Transparent polymer hybrids with the obtained polymer were prepared by using hydrogen bond interactions between amide g
- Ogoshi, Tomoki,Miyake, Junpei,Chujo, Yoshiki
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p. 4425 - 4431
(2007/10/03)
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- Polystyrene-bound cinchona alkaloids: Application to enantioselective electrophilic fluorination of silyl enol ethers
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A panoply of new polystyrene-bound cinchona alkaloids (PS-CA) has been prepared, and exploited for the design of unprecedented enantioselective electrophilic fluorinating agents. Compared to nonsupported [N-F]+ reagents, the polystyrene-bound N
- Thierry, Baptiste,Audouard, Christophe,Plaquevent, Jean-Christophe,Cahard, Dominique
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p. 856 - 860
(2007/10/03)
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- Polymer-bound self-folding cavitands
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The attachment of self-folding cavitands to polymeric supports has been succesfully demonstrated. Crosslinked polystyrene and PEGA were used. The synthesis of cavitands properly functionalized for this purpose is reported. The uptake of quest molecules by the resulting materials and the formation of inclusion complexes on the supports was demonstrated.
- Rafai Far, Adel,Lag Cho, Young,Rang, Alexander,Rudkevich, Dmitry M,Rebek Jr., Julius
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p. 741 - 755
(2007/10/03)
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- Cosmetic compositions
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Disclosed are cosmetic compositions comprising: (a) from about 0.1% to about 50%, based on the weight of the composition, of a film-forming graft copolymer, wherein the copolymer comprises: (i) a backbone exhibiting a Tg of from about 0 DEG C. to about 50 DEG C.; and (ii) one or more hydrophilic grafts attached to the backbone wherein each of the grafts exhibits a Tg of from about 50 DEG C. to about 200 DEG C., and wherein the average molecular weight of each of the grafts is greater than about 1000; and (b) from about 50% to about 99.9%, based on the weight of the composition, of a suitable carrier. The compositions provide good wear properties and are suitable for use in a variety of cosmetic applications, such as facial moisturizers, foundations, lipsticks, mascaras, nail polishes and the like. In a preferred embodiment, the compositions are in the form of a nail polish which, when applied to nails, exhibit excellent long wear properties.
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- 1,2-Dibenzamidobenzene inhibitors of human factor Xa
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High-throughput screening of a combinatorial library of diamidophenols yielded lead compounds with the ability to inhibit human factor Xa (fXa) at micromolar concentrations (e.g. compound 4, fXa apparent K(ass) = 0.64 x 106 L/mol). SAR studies in this novel structural series of fXa inhibitors showed that the phenolic hydroxyl group was not essential for activity. The best activity was found in substituted 1,2-dibenzamidobenzenes in which the phenyl group of one benzoyl group (A-ring) was substituted in the 4-position with relatively small lipophilic or polarizable groups such as methoxy, vinyl, or chloro and the phenyl group of the other benzoyl group (B-ring) was substituted in the 4-position with larger lipophilic groups such as tertbutyl or dimethylamino. The central phenyl ring (C-ring) tolerated a wide variety of substituents, but methoxy, methanesulfonamido, hydroxyl, and carboxyl substitution produced slightly higher levels of activity than other substituents when present in combination with favorable B-ring substitution. Methylation of the amide nitrogen atoms was found to greatly decrease activity. Compound 12 is the highest affinity fXa inhibitor in this group of compounds, having fXa apparent K(ass) = 25.5 x 106 L/mol, about 40x more active than the original lead. This lead series does not show potent inhibition of human thrombin. A model for the binding of these ligands to the fXa active site is proposed. The model is consistent with the observed SAR and can serve to guide future SAR studies.
- Herron, David K.,Goodson Jr., Theodore,Wiley, Michael R.,Weir, Leonard C.,Kyle, Jeffrey A.,Yee, Ying K.,Tebbe, Ann Louise,Tinsley, Jennifer M.,Mendel, David,Masters, John J.,Franciskovich, Jeffry B.,Sawyer, J. Scott,Beight, Douglas W.,Ratz, Andrew M.,Milot, Guy,Hall, Steven E.,Klimkowski, Valentine J.,Wikel, James H.,Eastwood, Brian J.,Towner, Richard D.,Gifford-Moore, Donetta S.,Craft, Trelia J.,Smith, Gerald F.
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p. 859 - 872
(2007/10/03)
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- 2-(4-alkenylphenyl)-5-oxazolones and polymers thereof
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Disclosed are certain 2-(4-alkenylphenyl-5-oxazolones useful in the production of polymers containing pendant functional groups obtained by nucleophilic ring-opening addition reactions, the 2-(4-alkenylphenyl)-5-oxazolones having the formula STR1 wherein
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- Preparation and Characterization of Some Nickel(II) Tetra-aza Macrocyclic Complexes bearing Pendant Polymerisable Groups as Part of the Ligand Superstructure
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The synthesis and characterisation of some new nickel(II) macrocyclic complexes of the 'lacunar' type have been performed where the ligand has, as part of the ligand superstructure, either 4-vinylphenyl or allyl groups capable of undergoing polymerisation reactions with selected comonomers.The n.m.r. spectra of a number of these new complexes show them to be fluxional on the n.m.r. time-scale and the nature of this fluxional behaviour is discussed.Some copolymerisation reactions of these complexes, with styrene or methyl methacrylate comonomers, have been performed.
- Cameron, James H.,Graham, Stephen
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p. 1599 - 1608
(2007/10/02)
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