- CERTAIN PROTEIN KINASE INHIBITORS
-
Provided are compound of formula (I) as certain CDK4/6 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.
- -
-
Paragraph 00142; 00143
(2015/12/18)
-
- CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS
-
Provided are certain dipeptidyl peptidase inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
- -
-
Page/Page column 18
(2011/07/08)
-
- NEW SUBSTITUTED AZATHYMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIOUS DISEASES
-
The invention relates to substituted azathymidines and related compounds of formula (I), wherein X is N or CH, and R1, R2 and R3 are as described in the specification, processes for the preparation thereof, pharmaceutical compositions containing the same, the use thereof optionally in combination with one or more other pharmaceutically active compounds as antibacterial agents for the therapy of infective diseases, and a method for the treatment of such diseases. The compounds of formula (I) are reducing selectively the pathogenicity of bacteria within the host, but without affecting the bacteria outside the host environment.
- -
-
Page/Page column 43; 46
(2008/06/13)
-
- Intramolecular Diels-Alder Reactions of 1,2,4-Triazines. Synthesis of Condensed Pyrimidines
-
1,2,4-Triazines with C5 tethered dienophilic side chains are sterically constrained to undergo intramolecular Diels-Alder reactions across the N2/C5 triazine positions; elimination of a nitrile from the intermediate adduct (N1 and C6 of the starting 1,2,4
- Taylor, Edward C.,Pont, Joseph L.
-
p. 4287 - 4292
(2007/10/02)
-
- Synthesis of New Substituted as-Triazine-6-carboxylic Acids and as-Triazine-6-yl-alkanoic Acids
-
New substituted 3-amino-, 5-amino- and 3,5-diamino-as-triazine-6-carboxylic acids 4a, b, 5a, b and 6 were obtained by the hydrolysis 6-azalumazine derivatives 3a-e.Corresponding acids of the structure 10a-d, 11a, b and 12 were synthesized from 5-chlor-3-m
- Heinisch, L.
-
p. 290 - 300
(2007/10/02)
-