1566-32-1

Basic information

• Product Name: AURORA 15003
• Synonyms: IFLAB-BB F1894-0137;AURORA 15003;6-METHYL-3-(METHYLTHIO)-1,2,4-TRIAZIN-5(4H)-ONE;6-methyl-3-(methylthio)-2H-1,2,4-triazin-5-one;6-methyl-3-methylsulfanyl-2H-1,2,4-triazin-5-one;6-Methyl-3-methylsulfanyl-4H-[1,2,4]triazin-5-one;6-methyl-3-(methylthio)-1,2,4-triazin-5(2H)-one
• CAS NO: 1566-32-1
• Molecular Formula: C₅H₇N₃OS
• Molecular Weight: 157.19
• Mol File: 1566-32-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 222-223 °C
• Boiling Point: 239.8°Cat760mmHg
• Flash Point: 98.8°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 0.0394mmHg at 25°C
• Refractive Index: 1.668
• PKA: 7.68±0.70(Predicted)
• CAS DataBase Reference: AURORA 15003(CAS DataBase Reference)
• NIST Chemistry Reference: AURORA 15003(1566-32-1)
• EPA Substance Registry System: AURORA 15003(1566-32-1)

Safety Data

• Hazardous Substances Data: 1566-32-1(Hazardous Substances Data)

Usage

General Description

AURORA 15003 is a chemical compound that consists of barium sulfate as its main component. It is commonly used as a contrasting agent for X-ray and CT imaging of the gastrointestinal tract. The barium sulfate in AURORA 15003 is inert and insoluble in water, making it an ideal substance for visualizing the digestive system. It is generally considered safe for use in medical imaging procedures, with few reported adverse effects. AURORA 15003 is typically administered orally or rectally, allowing for clear visualization of the digestive organs and their functioning during diagnostic procedures.

InChI:InChI=1/C5H7N3OS/c1-3-4(9)6-5(10-2)8-7-3/h1-2H3,(H,6,8,9)

Upstream product

• 615-76-9 6-aza-2-thiothymine 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 112081-00-2 (3-Methylsulfanyl-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl)-acetic acid 
• 112080-96-3 (3-Methylsulfanyl-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl)-acetic acid ethyl ester 
• 35600-34-1 S-methylisothiosemicarbazide hydroiodide 
• 127-17-3 2-oxo-propionic acid 

Downstream Products

• 89988-66-9 3-(N-methylanilino)-6-methyl-1,2,4-triazin-5(2H)-one 
• 89988-67-0 3-(N-methylanilino)-6-styryl-1,2,4-triazin-5(2H)-one 
• 925459-58-1 6-methyl-3-phenylmercapto-4H-[1,2,4]triazin-5-one 
• 42836-95-3 6-methyl-3-methylsulphanyl-[1,2,4]triazine 
• 685853-10-5 C₁₀H₁₀N₄O₂ 
• 1312954-47-4 2-((6-methyl-3-(methylthio)-5-oxo-1,2,4-triazin-4(5H)-yl)methyl)benzonitrile 

Relevant articles and documents

CERTAIN PROTEIN KINASE INHIBITORS

Provided are compound of formula (I) as certain CDK4/6 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

NEW SUBSTITUTED AZATHYMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIOUS DISEASES

The invention relates to substituted azathymidines and related compounds of formula (I), wherein X is N or CH, and R1, R2 and R3 are as described in the specification, processes for the preparation thereof, pharmaceutical compositions containing the same, the use thereof optionally in combination with one or more other pharmaceutically active compounds as antibacterial agents for the therapy of infective diseases, and a method for the treatment of such diseases. The compounds of formula (I) are reducing selectively the pathogenicity of bacteria within the host, but without affecting the bacteria outside the host environment.

Intramolecular Diels-Alder Reactions of 1,2,4-Triazines. Synthesis of Condensed Pyrimidines

1,2,4-Triazines with C5 tethered dienophilic side chains are sterically constrained to undergo intramolecular Diels-Alder reactions across the N2/C5 triazine positions; elimination of a nitrile from the intermediate adduct (N1 and C6 of the starting 1,2,4