2'-O- and 3'-O- pyrimidine aminotether-containing oligonucleotides: Synthesis and conjugation chemistry
Nucleoside synthons carrying an aminohexyl moiety tethered at the 2'-O- or 3'-O- positions of uridine have been synthesized and incorporated into oligonucleotides. The aminohexyl tether was used to conjugate functionalities such as intercalators, nucleic
OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION
The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.
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Page/Page column 276; 277; 278; 279
(2015/02/02)
Base-Sequence Dependence of Emission Lifetimes for DNA Oligomers and Duplexes Covalently Labeled with Pyrene: Relative Electron-Transfer Quenching Efficiencies of A, G, C, and T Nucleosides toward Pyrene
This paper reports both continuous and time-resolved spectroscopic studies of the emission properties of photoexcited pyrene labels covalently attached to uridine nucleosides and oligonucleotides.For all nucleic acid systems, uridine is substituted with p
Manoharan, Muthiah,Tivel, Kathleen L.,Zhao, Min,Nafisi, Kambiz,Netzel, Thomas L.
p. 17461 - 17472
(2007/10/02)
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