- Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill
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Using a ball mill, rapid, atom-economic coupling between adenosine-5′-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or barium salts was achieved. Facile purification by reversed-phase HPLC enabled product isolation within hours.
- Ravalico, Francesco,Messina, Ivano,Berberian, M. Victoria,James, Stuart L.,Migaud, Marie E.,Vyle, Joseph S.
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Read Online
- A fast and green preconcentration method based on surfactant ion pair-switchable solvent dispersive liquid–liquid microextraction for determination of phenazopyridine in pharmaceutical and biological samples
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Herein, a novel, fast, green and sensitive surfactant ion pair-switchable solvent dispersive liquid–liquid microextraction (SIP-SS-DLLME) method was developed for the preconcentration of phenazopyridine. Protonated triethylamine bicarbonate is synthesized
- Hamid, Yahya,Fat’hi, Mohammad Reza
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Read Online
- Eco-friendly and techno-economic conversion of CO2 into calcium formate, a valuable resource
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The suppression of greenhouse gas emissions is being considered more important than ever, and consequently, the development of methods to produce useful CO2 conversion products with excellent techno-economic feasibility and high CO2 reduction capability is of interest. A continuous CO2 conversion system and a heterogenized hydrogenation catalyst can be used to develop a process for the efficient and selective production of Ca(HCO2)2, which has not been considered as a CO2 conversion product so far, from waste resources, including CaO. Techno-economic analysis of the entire process showed that the production cost of Ca(HCO2)2 was reduced by around 16% compared with the conventional process, indicating a high possibility of market penetration. Furthermore, the estimation of the global warming index of the process through a life-cycle assessment showed that the global warming index could be reduced by about 20% compared with that of existing Ca(HCO2)2 production processes.
- Lee, Chul-Jin,Yoon, Ha-Jun,Yoon, Hayoung,Yoon, Sungho,Yoon, Taeksang
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p. 1738 - 1745
(2022/03/08)
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- Synthesis, characterization, and some properties of two types of new [Fe]-H2ase models containing a 4-phosphatopyridine or a 4-phosphatoguanosinepyridine moiety
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Two types of new [Fe]-H2ase models were synthesized using well-designed synthetic methods. The first type of trisubstituted pyridine ligand-containing models [2-MeOCH2-4-O2P(OPh)2-6-COCH2C5H2N]Fe(CO)2R (1, R = I; 2, R = EtS, 3, R = MeCOS), [2-MeOCH2-4-O2P(OPh)2-6-COCH2C5H2N]Fe(CO)2(MeCN)BF4 (4) and [2-MeOCH2-4-O2P(OPh)2-6-COCH2C5H2N]Fe(CO)(PPh3)I (5) were synthesized on the basis of preparing the new trisubstituted pyridine precursors L1-L6, whereas the second type of pentasubstituted pyridine ligand-containing model [2-MeO-3,5-Me2-4-OPO(OPh)O-5′-(N2-iPrCO-2′,3′-O-CMe2-guanosine)-6-COCH2C5N]Fe(CO)2(η2-6-Me-2-SC5H3N) (6) was synthesized via the esterification reaction of a new phosphatoguanosine derivative L7 with the corresponding pentasubstituted pyridine ligand-containing precursor (2-MeO-4-HO-3,5-Me2-6-COCH2C5N)Fe(CO)2(η2-6-Me-2-SCH5H3N) (D) in the presence of the dehydrating agent DCC. While all the new precursors L1-L7 and models 1-6 were fully characterized via elemental analysis and various spectroscopic techniques, the molecular structures of model 5 and precursor D were confirmed via X-ray crystallography. In addition, model 1 has been found to be a catalyst for proton reduction to H2 from TFA under CV conditions.
- Song, Li-Cheng,Chen, Wei,Zhu, Liang,Hu, Fu-Qiang,Jiang, Kai-Yu
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p. 18496 - 18507
(2020/11/13)
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- Structure-function study of tertiary amines as switchable polarity solvents
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A series of tertiary amines have been screened for their function as switchable polarity solvents (SPS). The relative ratios of tertiary amine and carbonate species as well as maximum possible concentration were determined through quantitative 1H and 13C NMR spectroscopy. The viscosities of the polar SPS solutions were measured and ranged from near water in dilute systems through to gel formation at high concentrations. The van't Hoff indices for SPS solutions were measured through freezing point depression studies as a proxy for osmotic pressures. A new form of SPS with an amine:carbonate ratio significantly greater than unity has been identified. Tertiary amines that function as SPS at ambient pressures appear to be limited to molecules with fewer than 12 carbons. The N,N-dimethyl-n-alkylamine structure has been identified as important to the function of an SPS.
- Wilson, Aaron D.,Stewart, Frederick F.
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p. 11039 - 11049
(2014/03/21)
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- Synthesis of uracil nucleotide analogs with a modified, acyclic ribose moiety as P2Y2 receptor antagonists
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A series of new uracil nucleotide analogs (monophosphates, triphosphates, and phosphonates) was synthesized, in which the ribose moiety was replaced by acyclic chains, including branched or linear alkyl or dialkylether linkers. 1-ω-Bromoalkyluracil deriva
- Sauer, Roland,El-Tayeb, Ali,Kaulich, Marko,Mueller, Christa E.
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supporting information; experimental part
p. 5071 - 5079
(2009/11/30)
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- PHOSPHORYLATED A2A RECEPTOR AGONISTS
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A phosphorylated A2A receptor agonist providing agonist properties on the A2A receptor after dephosphorylation the phosphorylated A2A receptor agonist comprises a ribosyl moiety and a purine moiety and being phosphorylated at the 5'-position of the ribose moiety except adenosine monophosphate (AMP), adenosine diphosphate (ADP) or adenosine triphosphate (ATP), a medicament containing the compound of the invention including ADP and the use of the compound of the invention including ATP and ADP for several medical indications e. g. inflammatory events. In particular, compounds of formula (I) are also disclosed.
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Page/Page column 18
(2008/06/13)
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- 1-dethia-2-thia-cephalosporanic acids
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Novel 1-dethia-2-thia-cephalosporanic acid derivatives of the formula STR1 wherein R is selected from the group consisting of STR2 Ra is an organic radical, Ri and Rj are individually selected from the group consisting of hydrogen, aliphatic, aromatic and heterocycle or taken together with the nitrogen atom to which they are attached form an optionally substituted cycle or Rb NH--, Rb is optionally substituted carbocyclic or heterocyclic aryl, R1 and --COM are as defined in the specification, R4 is hydrogen or methoxy, n2 is 0, 1 or 2 and their non-toxic, pharmaceutically acceptable acid addition salts in racemic or optically active form having antibiotic activity and their preparation and novel intermediates.
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