15720-17-9

Basic information

• Product Name: 4-(HYDROXYMETHYL)-D-PHENYLALANINE
• Synonyms: (2R)-2-AMINO-3-[4-(HYDROXYMETHYL)PHENYL]PROPANOIC ACID;D-Phenylalanine, 4-(hydroxyMethyl)-
• CAS NO: 15720-17-9
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.22
• Mol File: 15720-17-9.mol

Chemical Properties

• Boiling Point: 397°C at 760 mmHg
• Flash Point: 193.9°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 5.14E-07mmHg at 25°C
• Refractive Index: 1.602
• PKA: 2.21±0.10(Predicted)
• CAS DataBase Reference: 4-(HYDROXYMETHYL)-D-PHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(HYDROXYMETHYL)-D-PHENYLALANINE(15720-17-9)
• EPA Substance Registry System: 4-(HYDROXYMETHYL)-D-PHENYLALANINE(15720-17-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 15720-17-9(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
4-(Hydroxymethyl)-D-phenylalanine is utilized as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with specific therapeutic targets.
Used in Drug Development:
In the pharmaceutical industry, 4-(Hydroxymethyl)-D-phenylalanine is employed as a precursor in the creation of novel therapeutic agents. Its incorporation into drug molecules may enhance their efficacy, selectivity, or stability, contributing to the advancement of medicinal treatments.
Used in Research and Development:
4-(Hydroxymethyl)-D-phenylalanine serves as a valuable tool in scientific research, particularly in studies aimed at understanding the structure-activity relationships of pharmaceutical compounds. It aids researchers in identifying new drug candidates and optimizing their pharmacological profiles.
While the provided materials do not specify distinct applications in various industries, the general uses outlined above encompass the potential roles of 4-(Hydroxymethyl)-D-phenylalanine in the broader context of pharmaceutical and chemical research and development. Further exploration and experimentation are necessary to uncover more specific applications and optimize its utility in these fields.

InChI:InChI=1/C10H13NO3/c11-9(10(13)14)5-7-1-3-8(6-12)4-2-7/h1-4,9,12H,5-6,11H2,(H,13,14)/t9-/m1/s1

Upstream product

• 160916-46-1 N-boc-4-hydroxymethylphenylalanine 
• 15742-86-6 N-Acetyl (4-hydroxymethyl)-DL-phenylalanine 
• 1991-87-3 4-methyl-L-phenylalanine 
• 112766-18-4 methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-L-tyrosinate 
• 113850-76-3 N-(tert-butoxycarbonyl)-4-iodo-L-phenylalanine methyl ester 
• 216774-45-7 methyl 2-(S)-((tert-butoxycarbonyl)amino)-3-(4'-formyl-phenyl)propanoate 
• 216774-50-4 N-tert-butyloxycarbonyl-(p-hydroxymethyl)-L-phenylalanine methyl ester 

Relevant articles and documents

An improved preparation of 4-hydroxymethyl-L-phenylalanine

Palladium-catalyzed hydroformylation of methyl esters of N-Boc-L- tyrosine triflate (1a) and N-Boc-4-iodo-L-phenylalanine (1b) followed by reduction with sodium borohydride and standard deprotection procedures affords the title compound in 77 and 83% over

Intrinsic deuterium isotope effects on benzylic hydroxylation by tyrosine hydroxylase

Tyrosine hydroxylase (TyrH) is a mononuclear, non-heme iron monooxygenase that catalyzes the pterin-dependent hydroxylation of tyrosine to dihydroxyphenylalanine. When 4-methylphenylalanine is used as a substrate for TyrH, 4-hydroxymethylphenylalanine is

NOVEL MULTIMERIC MOLECULES, A PROCESS FOR PREPARING THE SAME AND THE USE THEREOF FOR MANUFACTURING MEDICINAL DRUGS

The invention relates to a compound of the formula (I): in which k and j are independently 0 or 1, Y is a macrocycle in which the cycle includes 9 to 36 carbon atoms and is functionalised by three amino functions and by a chain for attaching the spacer arm Z via an X bond, Rc is a binding pattern with a receptor of the TNF superfamily, X is a chemical function for binding the Y group to the space arm, and Z is a bi-, tri- or tetra-functional spacer arm.

NOVEL MULTIMERIC CD40 LIGANDS, METHOD FOR PREPARING SAME AND USE THEREOF FOR PREPARING DRUGS

The invention concerns a compound of formula (I), wherein Y represents a macrocycle whereof the cycle comprises 9 to 36 atoms, and is functionalized by three amine or COOH functions; Rc represents a group of formula H—Xa—Xb—Xc—Xd—Xe—(Xf)i—, wherein i represents 0 or 1, Xn is in particular selected among lysine, arginine, ornithine residues, Xb is in particular selected among glycine, asparagine, L-proline or D-proline residues, Xc et Xd are in particular selected among tyrosine, phenylalanine or 3-nitrotyrosine residues, Xe et Xf are in particular selected among the following amino acid residues: NH2—(CH2)n—COOH, n ranging from 1 to 10 or NH2—(CH2—CH2—O)m—CH2CH2COOH, m ranging from 3 to 6, provided that one at least of the amino acid residues Xa, Xb, Xc and Xd is different from the corresponding amino acid in the sequence of the natural CD40 143Lys-Gly-Tyr-Tyr146 fragment

(p-Sulfomethyl)phenylalanine as a mimic of O-sulfatyl-tyrosine in synthetic partial sequences of P-Selectin glycoprotein ligand 1 (PSGL-1)

Fmoc-l-(p-sulfomethyl)phenylalanine, a bioisosteric mimic of acid-sensitive O-sulfatyl tyrosine, was synthesized from l-tyrosine according to a novel route. Partial sequences of the recognition site of P-Selectin glycoprotein ligand 1 (PSGL-1), which cont

Synthesis of novel chiral amino acids possessing a porphyrin moiety

Phenylalanine derivatives bearing a porphyrin moiety at the para- position were prepared in an enantiomerically pure form. The synthetic nonnatural aromatic amino acid reacted with amines and acids to give novel functionalized peptides without loss of the