- Method of inhibiting binding of nerve growth factor to p75 NTR receptor
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The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTRcommon neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75NTRcomprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lys34of nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lys95of nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lys88of nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lys32of nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile31, Phe101and Phe86of nerve growth factor.
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- 3- and 4-Azidophthalic acid derivatives
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The compounds according to the invention have the formulae Ia or Ib STR1 in which Y is a divalent organic radical and Z is --NH2, --NH-alkyl having 1-4 C atoms, --OH, --COOH, --COCl, --O--CO--CH=CH2, STR2 --COO--CH=CH2 or
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