15728-06-0

Basic information

• Product Name: 6-(4-nitro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexanoic acid
• Synonyms: 2H-isoindole-2-hexanoic acid, 1,3-dihydro-4-nitro-1,3-dioxo-
• CAS NO: 15728-06-0
• Molecular Formula: C₁₄H₁₄N₂O₆
• Molecular Weight: 306.2708
• Mol File: 15728-06-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 539.2°C at 760 mmHg
• Flash Point: 279.9°C
• Density: 1.44g/cm³
• Vapor Pressure: 1.85E-12mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 6-(4-nitro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-nitro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexanoic acid(15728-06-0)
• EPA Substance Registry System: 6-(4-nitro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexanoic acid(15728-06-0)

Safety Data

• Hazardous Substances Data: 15728-06-0(Hazardous Substances Data)

Upstream product

• 641-70-3 3-nitrophthalic acid anhydride 
• 60-32-2 6-aminohexanoic acid 

Relevant articles and documents

Method of inhibiting binding of nerve growth factor to p75 NTR receptor

The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTRcommon neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75NTRcomprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lys34of nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lys95of nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lys88of nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lys32of nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile31, Phe101and Phe86of nerve growth factor.