157837-31-5

Basic information

• Product Name: 3-(1,3-OXAZOL-5-YL)ANILINE
• Synonyms: 3-(1,3-OXAZOL-5-YL)ANILINE;5-(3-AMINOPHENYL)OXAZOLE;BUTTPARK 43\57-51;3-(oxazol-5-yl)benzenaMine;3-(5-Oxazolyl)aniline;[3-(1,3-Oxazol-5-yl)phenyl]amine;[3-(Oxazol-5-yl)phenyl]amine;3-(5-Oxazolyl)benzenamine
• CAS NO: 157837-31-5
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• Product Categories: Amines and Anilines;Heterocycles;Amines;Phenyls & Phenyl-Het;API intermediates;Phenyls & Phenyl-Het
• Mol File: 157837-31-5.mol

Chemical Properties

• Melting Point: 93-95°C
• Boiling Point: 359.1 °C at 760 mmHg
• Flash Point: 171 °C
• Appearance: /
• Density: 1.204
• Vapor Pressure: 2.43E-05mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.81±0.10(Predicted)
• CAS DataBase Reference: 3-(1,3-OXAZOL-5-YL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,3-OXAZOL-5-YL)ANILINE(157837-31-5)
• EPA Substance Registry System: 3-(1,3-OXAZOL-5-YL)ANILINE(157837-31-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 157837-31-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(1,3-Oxazol-5-yl)aniline is utilized as a building block for the synthesis of various pharmaceuticals and bioactive compounds due to its unique structure and properties, which contribute to the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 3-(1,3-Oxazol-5-yl)aniline is employed as a reagent in chemical reactions, enabling the formation of diverse organic compounds with specific functionalities and applications.
Used in Medicinal Chemistry:
3-(1,3-Oxazol-5-yl)aniline is used as a precursor in the production of other organic compounds, particularly in medicinal chemistry, where it aids in the synthesis of compounds with potential medicinal properties, enhancing the discovery and development of new therapeutic agents.

InChI:InChI=1/C9H8N2O/c10-8-3-1-2-7(4-8)9-5-11-6-12-9/h1-6H,10H2

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 89808-77-5 5-(3-nitro-phenyl)-oxazole 

Downstream Products

• 1190221-55-6 5-chloro-2-([(2-([3-(1,3-oxazol-5-yl)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid 
• 1190223-05-2 methyl 5-chloro-2-{[(2-{[3-(1,3-oxazol-5-yl)phenyl]amino}-2-oxoethoxy)acetyl]amino}benzoate 
• 1428968-42-6 1-(1H-indol-3-yl)-2-((3-(oxazol-5-yl)phenyl)amino)-2-phenylethanone 
• 1416337-41-1 5-bromo-2-nitro-N-[3-(1,3-oxazol-5-yl)phenyl]aniline 
• 1416335-46-0 N-[5-{2-amino-1-[3-(1,3-oxazol-5-yl)phenyl]-1H-benzimidazol-6-yl}-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide 
• 1416337-43-3 6-bromo-1-[3-(1,3-oxazol-5-yl)phenyl]-1H-benzimidazol-2-amine 

Relevant articles and documents

Charge Transport and Quantum Interference Effects in Oxazole-Terminated Conjugated Oligomers

Charge transport in single molecule junctions critically depends on the chemical identity of anchor groups used to connect molecular wires to electrodes. In this work, we report the charge transport properties of conjugated oligomers with oxazole anchors,

NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK

The present invention is concerned with substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases s

DIAZASPIROALKANEONE-SUBSTITUTED OXAZOLE DERIVATIVES AS SPLEEN TYROSINE KINASE INHIBITORS

The present invention is concerned with diazaspiroalkanone- substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human a

UREA DERIVATIVES USEFUL AS CALCIUM RECEPTOR MODULATORS

The present invention provides compounds of formula (I): in which Y is oxygen or sulphur; R1 and R”1 are optionally substituted aryl, heteroaryl or a fused ring structure, R2and R'2 are each H, or optionally substituted alkyl, alkylaminoalkyl or dialkylaminoalkyl, or R2 and R'2 and their N form a saturated or unsaturated optionally substituted heterocycle, R3 represents a group of formula -(CH2)P-Ar-Rn, wherein p is 0 or 1 and, when p is 1, is optionally substituted, Ar is aryl or heteroaryl, and each R is H, halogen; hydroxyl; trifiuoromethyl; linear and branched alkyl, alkenyl, alkynyl, and alkoxyl groups, all optionally further substituted by one or more of hydroxy groups, halogen atoms, alkoxy groups, amino groups, and alkylthio groups; linear and branched alkoxyl groups; linear and branched thioalkyl groups; aryl groups; aralkyl groups; aralkoxy groups; aryloxy groups; perfluoroalkyl; -CN; -NR4R5, -C(=X)NR4R5,-O-C(=X)NR4R5, -SO2NR4R5, - Alk-NR4R5, -NZC(=X)(NH)qR6, -Alk-NZC(=X)(NH)qR6, -C(=X)R6, -Alk-C(=X)(NH)qR6, -NHSO2R7, -SO2R7, -SOR7, -SR7, or is a saturated or unsaturated heterocyclyl group, and salts and esters thereof, are useful in the treatment of conditions susceptible to modulating ion channels, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

HYDRAZONE DERIVATIVE

A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof