The present invention relates to fluorescent dyes based on acridine derivatives and use of such dyes, for example, in biochemical and/or cell based assays. A preferred feature of some of the dyes described is their long fluorescence lifetimes and their us
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Paragraph 0133-0135; 0145-0149
(2014/04/04)
9-Aminoacridine peptide derivatives as versatile reporter systems for use in fluorescence lifetime assays
A novel long lifetime fluorescence reporter based on 9-aminoacridine was designed, the lifetime of which can be modulated in a defined manner when in proximity to a tryptophan residue enabling fluorescence lifetime based biochemical assays to be configure
Maltman, Beatrice A.,Dunsmore, Colin J.,Couturier, Sarah C. M.,Tirnaveanu, Adina E.,Delbederi, Zoica,McMordie, R. Austin S.,Naredo, Gregorio,Ramage, Robert,Cotton, Graham
supporting information; scheme or table
p. 6929 - 6931
(2010/11/04)
Enhancement of mutagenic activity of 9-aminoacridine by introducing a nitro group into the molecule.
Mutagenic activity and DNA intercalation were examined for 9-aminoacridine (9-AA) and its derivatives. Introduction of a nitro group into the 9-AA molecule was found to enhance the activity enormously as was detected by the Ames test. Acetylation of amino group at 9-position of acridine ring inhibited the intercalation, the frameshift activity disappearing. Rat liver S9 converted 9-AA metabolically to 9-amino-2-hydroxyacridine.
Tomosaka,Omata,Anzai
p. 1420 - 1423
(2007/10/02)
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