157996-59-3Relevant articles and documents
NOVEL FLUORESCENT DYES AND USES THEREOF
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Paragraph 0133-0135; 0145-0149, (2014/04/04)
The present invention relates to fluorescent dyes based on acridine derivatives and use of such dyes, for example, in biochemical and/or cell based assays. A preferred feature of some of the dyes described is their long fluorescence lifetimes and their us
Enhancement of mutagenic activity of 9-aminoacridine by introducing a nitro group into the molecule.
Tomosaka,Omata,Anzai
, p. 1420 - 1423 (2007/10/02)
Mutagenic activity and DNA intercalation were examined for 9-aminoacridine (9-AA) and its derivatives. Introduction of a nitro group into the 9-AA molecule was found to enhance the activity enormously as was detected by the Ames test. Acetylation of amino group at 9-position of acridine ring inhibited the intercalation, the frameshift activity disappearing. Rat liver S9 converted 9-AA metabolically to 9-amino-2-hydroxyacridine.