Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1.5
The voltage-gated potassium channel Kv1.5 is regarded as a promising target for the development of new atrial selective drugs with fewer side effects. In the present study the discovery of ortho, ortho-disubstituted bisaryl compounds as blockers of the Kv
Peukert, Stefan,Brendel, Joachim,Pirard, Bernard,Brüggemann, Andrea,Below, Peter,Kleemann, Heinz-Werner,Hemmerle, Horst,Schmidt, Wolfgang
p. 486 - 498
(2007/10/03)
Antiparallel β-sheet conformation in cyclopeptides containing a pseudo-amino acid with a biphenyl moiety
The biphenyl-containing pseudo-amino acids 2'-(aminomethyl)biphenyl-2-carboxylic acid (Abc; 1) and 2'-(aminomethyl)biphenyl-2-acetic acid (Aba; 2) are used as rigid spacers in the backbone of the cyclic peptides cyclo (-Abc-Ala-Phe-Gly-)2 (5),
Brandmeier,Sauer,Feigel
p. 70 - 85
(2007/10/02)
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