31638-34-3

Usage

Chemical Class

Biphenyl carboxylic acids

Functional Groups

Aminomethyl group attached to the second carbon of one biphenyl ring, carboxylic acid group attached to the second carbon of the other biphenyl ring

Potential Applications

Medicinal chemistry, drug development

Use as Building Block

In organic synthesis to produce other compounds with specific properties or functions

Further Research Needed

To fully understand potential uses and effects.

Upstream product

• 14140-04-6 phenanthrene-9,10-dione oxime 
• 119297-30-2 2'-(phthalimidomethyl)biphenyl-2-carboxylic acid 
• 57743-13-2 2'-cyano-[1,1'-biphenyl]-2-carboxylic acid 

Downstream Products

• 158066-18-3 Boc-Abc-Ala-Val-Gly-Abc-Ala-Val-Gly-OMe 
• 158066-17-2 Boc-Abc-Ala-Phe-Gly-Abc-Ala-Phe-Gly-OMe 
• 158066-13-8 methyl <2'-<<(tert-butyloxy)carbonyl>aminomethyl>biphenyl-2-carbonyl>-L-alanyl-L-phenylalanyl-glycinate 
• 195515-94-7 2'-({[(S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid 
• 498577-62-1 [2'-(2,4-difluorobenzylcarbamoyl)biphenyl-2-ylmethyl]carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

PEPTIDES AND PEPTIDOMIMETIC COMPOUNDS, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION

Peptides, peptidomimetics and derivatives thereof of the general formula I: H2N-GHRPX1-β-X4X5X6X7X8X9X10-X11 (I), in which X1-X10 denote one of the 20 genetically coded amino acids, wherein X8, X9 and X10 may also denote a single chemical bond;X11 denotes OR1 in which R1 equals hydrogen or (C1-C10) alkyl NR2R3 with R2 and R3 are equal or different and denote hydrogen, (C1-C10) alkyl, or a residue —W-PEG5-60K, in which the PEG residue is attached via a suitable spacer W to the N-atom, ora residue NH—Y-Z-PEG5-60K, in whichY denotes a chemical bond or a genetically coded amino acids from the group S, C, K or R andZ denotes a spacer, via which a polyethylene glycol (PEG)-residue can be attached, and their physiologically acceptable salts, andβ denotes an amino acid, or a peptidomimetic element, which induces a bend or turn in the peptide backbone.

Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1.5

The voltage-gated potassium channel Kv1.5 is regarded as a promising target for the development of new atrial selective drugs with fewer side effects. In the present study the discovery of ortho, ortho-disubstituted bisaryl compounds as blockers of the Kv

Antiparallel β-sheet conformation in cyclopeptides containing a pseudo-amino acid with a biphenyl moiety

The biphenyl-containing pseudo-amino acids 2'-(aminomethyl)biphenyl-2-carboxylic acid (Abc; 1) and 2'-(aminomethyl)biphenyl-2-acetic acid (Aba; 2) are used as rigid spacers in the backbone of the cyclic peptides cyclo (-Abc-Ala-Phe-Gly-)2 (5),

Synthesis and antifibrinolytic properties of some ε aminoacids

The authors have synthesized some ε aminoacids and investigated their antifibrinolytic activity. Two of them, α aminocampholic acid and d,1 cis 2,2 dimethyl α 3 aminoethyl) cyclobutane acetic acid, which are prepared by catalytic hydrogenation of respective cyanoacid and oxime acid possess an activity slightly superior to that of ε aminocaproic acid actually used in therapy.