Efficient solvent free synthesis of tertiary α-aminophosphonates using H2Ti3O7 nanotubes as a reusable solid-acid catalyst
In this paper, TiO2 fine particles, TiO2-P25, protonated trititanate (H2Ti3O7) nanorods and nanotubes were used as recyclable solid-acid catalysts for the solvent free synthesis of tertiary α-aminopho
Reddy, Bhoomireddy Rajendra Prasad,Reddy, Peddiahgari Vasu Govardhana,Reddy, Bijivemula N.
p. 9605 - 9610
(2015/12/01)
Copper-catalyzed α-amination of phosphonates and phosphine oxides: A direct approach to α-amino phosphonic acids and derivatives
A direct approach to important α-amino phosphonic acids and its derivatives has been developed by using copper-catalyzed electrophilic amination of α-phosphonate zincates with O-acyl hydroxylamines. This amination provides the first example of C=N bond formation which directly introduces acyclic and cyclic amines to the α-position of phosphonates in one step. The reaction is readily promoted at room temperature with as little as 0.5 mol % of catalyst, and demonstrates high efficiency on a broad substrate scope. A direct approach to important α-amino phosphonic acids and derivatives, by using copper-catalyzed electrophilic amination of α-phosphonate zincates using O-acylhydroxylamines, is described. This amination is the first example of C=N bond formation which directly introduces acyclic and cyclic amines to the α-position of phosphonates in one step. The reaction proceeds at room temperature with as little as 0.5 mol % of the catalyst. Copyright
McDonald, Stacey L.,Wang, Qiu
supporting information
p. 1867 - 1871
(2014/03/21)
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