Efficient C(sp3)-H bond functionalization of isochroman by azadol catalysis
A novel organocatalytic C(sp3)-H bond functionalization of isochroman under practical conditions has been developed. In the presence of 5.0 mol % of AZADOL, the catalysis proceeded successfully with a broad range of substrates and nucleophiles in excellent yields.
Organocatalytic approach for C(sp3)-H bond arylation, alkylation, and amidation of isochromans under facile conditions
A new catalytic approach for the synthesis of isochroman derivatives via direct C(sp3)-H bond arylation is described. The oxidation reaction with [bis(trifluoroacetoxy)iodo]benzene facilitates the regeneration of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in the C(sp3)-H bond arylation of isochroman. The reaction conditions can also be used for alkyl Grignard reagents and amides to afford the corresponding isochroman derivatives.
Muramatsu, Wataru,Nakano, Kimihiro
supporting information
p. 2042 - 2045
(2014/05/06)
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