Synthesis 2-substituted 6-fluoroalkylpyrimidin-4(3H)-ones and -pyrimidines
Treatment of ethyl α-fluoroalkylacetates 1 or ethyl 3-fluoroalkyl-2-iodoacrylates 2 under mild conditions with amidine affords 2-substituted 6-fluoroalkylpyrimidin-4(3H)-ones 4, 5, 6, 7 in excellent yields, while α-fluoroalkyl alkyl ketones or α-fluoroalk