Synthesis p. 997 - 1001 (1996)
Update date:2022-08-03
Topics:
Guan, Hui-Ping
Hu, Qiao-Sheng
Hu, Chang-Ming
Treatment of ethyl α-fluoroalkylacetates 1 or ethyl 3-fluoroalkyl-2-iodoacrylates 2 under mild conditions with amidine affords 2-substituted 6-fluoroalkylpyrimidin-4(3H)-ones 4, 5, 6, 7 in excellent yields, while α-fluoroalkyl alkyl ketones or α-fluoroalk
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