158732-59-3

Basic information

• Product Name: 2-Propenoic acid,3-[2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-, (2E)-
• Synonyms: 2-Propenoic acid,3-[2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-, (2E)- ;Salvianolic acid F;(2E)-3-[2-[(1E)-2-(3,4-Dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-2-propenoic acid
• CAS NO: 158732-59-3
• Molecular Formula: C17H14O6
• Molecular Weight: 314.28946
• Mol File: 158732-59-3.mol

Chemical Properties

• Boiling Point: 636.8±55.0 °C(Predicted)
• Appearance: /
• Density: 1.556±0.06 g/cm3(Predicted)
• PKA: 4.55±0.15(Predicted)
• CAS DataBase Reference: 2-Propenoic acid,3-[2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid,3-[2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-, (2E)-(158732-59-3)
• EPA Substance Registry System: 2-Propenoic acid,3-[2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-, (2E)-(158732-59-3)

Safety Data

• Hazardous Substances Data: 158732-59-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Propenoic acid,3-[2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-, (2E)is used as a pharmaceutical compound for its potential therapeutic effects. Its unique structure allows it to interact with various biological targets, making it a promising candidate for the development of new drugs.
Used in Traditional Chinese Medicine (TCM):
2-Propenoic acid,3-[2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-, (2E)is used as an active ingredient in TCM, particularly in the treatment of cardiovascular and cerebrovascular diseases. Its presence in Danshen, a well-known TCM, highlights its potential benefits in these areas.
Used in Drug Delivery Systems:
Similar to gallotannin, 2-Propenoic acid,3-[2-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-, (2E)can be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. The development of novel carriers, such as organic and metallic nanoparticles, can improve the delivery and efficacy of this compound in various applications.

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Relevant articles and documents

Towards the first synthesis of salvianolic acid F: An unexpected intramolecular Diels-Alder cyclisation

The reaction of tetramethylsalvianolic acid F3 with BBr3 led to the expected salvianolic acid F 2 in 10% yield. 2 underwent Diels-Alder cyclisation to 5 or cyclisation to benzofuran 6 depending on the reaction conditions.

Preparation method of salvianolic acid F

The invention relates to a preparation method of salvianolic acid F, which includes a step of performing a reaction to trans-3-(2-(trans-3,4-disubstituted-styryl)-3,4-disubstituted-phenyl)acrylate under effect of aluminum salt and alkali in a solvent to p

New synthesis method of natural product Salvianolic Acid F

The invention discloses a new synthesis method of a natural product Salvianolic Acid F. The method comprises the following steps: carrying out hydroxyl group protection on 4-methycatechol used as a raw material, carrying out a methyl radical reaction, and

Chemical conversions of salvianolic acid B by decoction in aqueous solution

Salvianolic acid B (Sal B) is the most abundant phenolic compound in Salvia miltiorrhiza, which has been widely used for the treatment of cardiovascular diseases in Oriental medicine. To elucidate structure of the converted compounds of Sal B by decoction

The total synthesis of salvianolic acid F

An expeditious synthesis of salvianolic acid F 2 is described in 10% overall yield. Tetramethyl salvianolic acid F 3 was obtained in six steps in 39% overall yield and was converted into the target molecule using boron tribromide in 26% yield.