83983-71-5Relevant academic research and scientific papers
Enantioselective Alkynylation of Trifluoromethyl Ketones Catalyzed by Cation-Binding Salen Nickel Complexes
Park, Dongseong,Jette, Carina I.,Kim, Jiyun,Jung, Woo-Ok,Lee, Yongmin,Park, Jongwoo,Kang, Seungyoon,Han, Min Su,Stoltz, Brian M.,Hong, Sukwon
supporting information, p. 775 - 779 (2019/12/24)
Cation-binding salen nickel catalysts were developed for the enantioselective alkynylation of trifluoromethyl ketones in high yield (up to 99 %) and high enantioselectivity (up to 97 % ee). The reaction proceeds with substoichiometric quantities of base (
The first total synthesis of (±)-methyl salvianolate A using a convergent strategy
Wang, Bo,Wang, Liping,Peng, Ying,Pang, Yiying,Xiao, Hesheng,Wang, Xiaoji,Huang, Shuangping
, (2019/03/19)
Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner–Wadsworth–Emmons reaction and the protection of multiple hydroxyls using s
Method for synthesizing natural product salvianolic acid A methyl ester
-
, (2017/07/20)
The invention relates to a novel method for synthesizing natural product salvianolic acid A methyl ester. A synthetic route is unique and novel in design; key strategies and steps comprise the step of using an easily-removed t-butyldimethylsilyl protectin
New synthesis method of natural product Salvianolic Acid F
-
, (2018/01/04)
The invention discloses a new synthesis method of a natural product Salvianolic Acid F. The method comprises the following steps: carrying out hydroxyl group protection on 4-methycatechol used as a raw material, carrying out a methyl radical reaction, and
CYSTOBACTAMIDES
-
Paragraph 0393; 0394; 0395; 0396, (2016/06/13)
The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections:
TRICYCLIC BENZOXABOROLES AS ANTIBACTERIAL AGENTS
-
Page/Page column 46; 47, (2016/01/25)
The present invention provides a tricyclic compound represented by general formula (I), a pharmaceutical salt thereof, or a stereoisomer thereof exhibits excellent antibacterial activity against Gram-negative bacteria resistant bacteria thereof, and also
Synthesis and biological evaluation of cystobactamid 507: A bacterial topoisomerase inhibitor from Cystobacter sp.
Moreno, María,Elgaher, Walid A.M.,Herrmann, Jennifer,Schl?ger, Nadin,Hamed, Mostafa M.,Baumann, Sascha,Müller, Rolf,Hartmann, Rolf W.,Kirschning, Andreas
supporting information, p. 1175 - 1178 (2015/06/02)
Abstract The first total synthesis of cystobactamid 507, a member of a class of new natural products with strong inhibitory activity towards bacterial topoisomerases, is reported. Synthetic key challenges are the central tetrasubstitued arene and the low chemical reactivity of anilines and ortho-phenolic and isopropoxy-substituted benzoic acids. Biological evaluations demonstrate that cystobactamid 507 inhibits several Gram-positive pathogens but at significantly lower concentrations than described for the larger members of this natural product family.
An efficient synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide
Wang, Chaolei,Wu, Zheng,Wang, Jia,Liu, Jie,Yao, Hequan,Lin, Aijun,Xu, Jinyi
, p. 8172 - 8177 (2015/12/30)
The synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide as the internal electrophilic group, t-BuLi as the lithium reagent was described. The reaction was efficient and could be completed in one minute. The application scope of this new protocol was investigated and the desired products could be obtained in good to excellent yields. Besides, the synthetic potential of this method was further demonstrated by the synthesis of natural product (±)-XJP, which was obtained in six steps with overall yield up to 54%.
First total synthesis of antihypertensive natural products S-(+)-XJP and R-(-)-XJP
Wang, Chaolei,Wei, Guoxiang,Yang, Xue,Yao, Hequan,Jiang, Jieyun,Liu, Jie,Shen, Mingqin,Wu, Xiaoming,Xu, Jinyi
, p. 7338 - 7344 (2014/11/08)
The first asymmetric total synthesis of antihypertensive natural products S-(+)-XJP and R-(-)-XJP has been achieved in 8 steps starting from commercially available 6-bromo-2-hydroxy-3-methoxybenzaldehyde. Key steps included intramolecular Heck reaction an
Synthesis of oxidative dihydroxy metabolites of benzo[c]phenanthridines
Styskala, Jakub,Hlavá?, Jan,Canka?, Petr
, p. 4670 - 4678 (2013/06/27)
The synthesis of dihydroxybenzo[c]phenanthridines is described. 6-Bromo-2,3-dihydroxybenzaldehyde was reacted with naphtho[2,3-d][1,3]dioxol-5- amine via reductive amination to give the corresponding diol 19, which was subsequently protected with ethoxyme
