158980-46-2

Basic information

• Product Name: BENZHYDRYLAMINOACETIC ACID, TERT-BUTYL ESTER
• Synonyms: BENZHYDRYLAMINOACETIC ACID, TERT-BUTYL ESTER;TERT-BUTYL(DIPHENYLMETHYLAMINO)ETHANOATE;N-(Diphenylmethyl)glycine 1,1-Dimethylethyl Ester
• CAS NO: 158980-46-2
• Molecular Formula: C₁₉H₂₃NO₂
• Molecular Weight: 297.39
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Aromatics;Intermediates
• Mol File: 158980-46-2.mol

Chemical Properties

• Melting Point: 75.5-76.5°C
• Boiling Point: 393.745 °C at 760 mmHg
• Flash Point: 191.93 °C
• Appearance: /
• Density: 1.058 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.544
• CAS DataBase Reference: BENZHYDRYLAMINOACETIC ACID, TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: BENZHYDRYLAMINOACETIC ACID, TERT-BUTYL ESTER(158980-46-2)
• EPA Substance Registry System: BENZHYDRYLAMINOACETIC ACID, TERT-BUTYL ESTER(158980-46-2)

Safety Data

• Hazardous Substances Data: 158980-46-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
BENZHYDRYLAMINOACETIC ACID, TERT-BUTYL ESTER is used as a synthetic intermediate for the production of 2-Azetidinones, which are crucial in the development of various pharmaceutical compounds. These 2-Azetidinones have potential applications in the treatment of different medical conditions due to their unique chemical structures and properties.

InChI:InChI=1/C19H23NO2/c1-19(2,3)22-17(21)14-20-18(15-10-6-4-7-11-15)16-12-8-5-9-13-16/h4-13,18,20H,14H2,1-3H3

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 91-00-9 Benzhydrylamine 

Downstream Products

• 158980-47-3 N-(Diphenylmethyl)-N-(2-oxo-2-phenylethyl)glycine 1,1-dimethylethyl ester 
• 158980-49-5 N-(Diphenylmethyl)-N-(2-chloro-2-phenylethyl)glycine 1,1-dimethylethyl ester 
• 158980-48-4 N-(Diphenylmethyl)-N-(2-hydroxy-2-phenylethyl)glycine 1,1-dimethylethyl ester 
• 566202-61-7 (3S,4S,5R)-N-diphenylhydroxymethyl-3-(1'-hydroxyethyl)-4-(tert-butyloxyoxomethyl)azetidin-2-one 
• 566202-58-2 (3S,4S,5R)-N-diphenylmethyl-3-(1'-hydroxyethyl)-4-(tert-butyloxyoxomethyl)azetidin-2-one 
• 566202-56-0 tert-butyl (2'R,3'R)-2-[N-(diphenylmethyl)-N-(2',3'-epoxybutanoyl)amino]ethanoate 

Relevant articles and documents

N-HYDROXYAMIDE DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY

Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.

A new method of N-benzhydryl deprotection in 2-azetidinone series

A mild and efficient procedure for the selective cleavage of N-benzhydryl protecting group of β-lactams is described. The protected 2-azetidinones 4, precursors of carbapenems, were treated with a stoichiometric amount of N-bromosuccinimide and a catalyti