159029-33-1

Basic information

• Product Name: Methyl 3-aMino-2-(aMinoMethyl)propanoate
• Synonyms: Methyl 3-aMino-2-(aMinoMethyl)propanoate;Methyl 3-amino-2-(aminomethyl)
• CAS NO: 159029-33-1
• Molecular Formula: C₅H₁₂N₂O₂
• Molecular Weight: 132.16098
• Mol File: 159029-33-1.mol

Chemical Properties

• Boiling Point: 225.2±30.0 °C(Predicted)
• Appearance: /
• Density: 1.080±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.47±0.10(Predicted)
• CAS DataBase Reference: Methyl 3-aMino-2-(aMinoMethyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-aMino-2-(aMinoMethyl)propanoate(159029-33-1)
• EPA Substance Registry System: Methyl 3-aMino-2-(aMinoMethyl)propanoate(159029-33-1)

Safety Data

• Hazardous Substances Data: 159029-33-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 3-amino-2-(aminomethyl)propanoate is used as a starting material for the synthesis of other organic compounds, particularly in the pharmaceutical industry. It is used as a building block for the preparation of various drug molecules.
Used in Peptide Synthesis:
Methyl 3-amino-2-(aminomethyl)propanoate is used as a component in peptide synthesis due to its role in the formation of peptide bonds.
Used in Drug Development:
Methyl 3-amino-2-(aminomethyl)propanoate has potential applications in the development of new therapeutic agents and drugs.

Upstream product

• 159029-60-4 methyl 3-azido-2-(azidomethyl)propionate 
• 22262-60-8 methyl 3-bromo-2-(bromomethyl)propionate 
• 159029-61-5 methyl 3-((tert-butoxycarbonyl)amino)-2-(((tert-butoxycarbonyl)amino)methyl)propanoate 

Downstream Products

• 960389-33-7 methyl 8-(3-bromophenyl)-8-(4-methoxyphenyl)-6-thioxo-2,3,4,6,7,8-hexahydroimidazo[1,5-a]pyrimidine-3-carboxylate 

Relevant articles and documents

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We report the synthesis of a series of monoanionic phosphotyrosyl (pTyr) mimetic-containing tripeptides based on 'Fmoc-Glu(OBn)-Xxx-Leu-amide' (where Xxx = pTyr mimetic) and their N-terminally modified derivatives. The inhibitory potencies of compounds were tested against YopH and human PTP1B enzymes. Several compounds exhibited noteworthy activity against both YopH and PTP1B. Among the N-terminally modified analogues, 5-methylindole derivative 30 was found to be the best moiety to replace base-labile Fmoc group. A mode of binding with YopH is proposed for tripeptides 21, 30, and 31.

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An Efficient Synthesis of Some 6-Substituted 4,8-Diaza-3,3,9,9-tetramethylundeca-2,10-dione Dioximes (Propylene Amine Oximes, PnAOs): Ligands for 99mTc Complexes Used in Structure Distribution Relationship (SDR) Studies

Technetium complexes of the ligand PnAO are of interest as commercial radiopharmaceuticals.In general, PnAOs are synthesized by alkylation of a propylenediamine derivative with 3-chloro-3-methyl-2-nitrosobutane (2).This alkylation reaction proved to be low yielding.With modestly bulky substituents at the 2-position of 1,3-diaminopropane, little or none of the required PnAO was obtained.As a result, an alternative approach of the synthesis of PnAO was developed.This method involved the alkylation of the propylenediamine with 3-bromo-3-methylbutan-2-one (18) followed by oximation of the resulting diamine-diketone (19).By this method, PnAOs were prepared in good yield, even with bulky C-2 substituents.Fourteen PnAO derivatives were prepareed by this method.We also describe the syntheses of several new propylenediamine dervatives.