15908-50-6Relevant articles and documents
Second harmonic generation in push-pull ethylenes: Influence of chirality and hydrogen bonding
Mohanalingam,Nethaji,Das, Puspendu Kumar
, p. 177 - 188 (1996)
The effect of chiral substituents and hydrogen bonding functional groups on the microscopic and macroscopic second-order non-linearities in some donor-acceptor substituted ethylenes has been investigated. It appears that extensive intramolecular and intermolecular hydrogen bonding helps to improve both the microscopic hyperpolarizability (β) as well as the powder second harmonic generation (SHG) efficiency in these compounds. The substitution of the chiral α-methylbenzylamine donor guarantees a non-centrosymmetric structure. Cocrystallization with triphenylphosphine oxide (TPPO) does not appear to yield better SHG efficiency in the α-methylbenzylamine substituted ethylene compound which has an extended hydrogen bonding network.
An easy access to variously substituted pyrroles starting from ketene dithioacetals
Sommen, Geoffroy L.,Cornel, Alain,Kirsch, Gilbert
, p. 693 - 699 (2005)
Variously substituted pyrroles 4 can easily be synthesized in two steps by reacting a primary or secondary amine and a ketene dithioacetal in a basic medium in moderate to good yield. Ketene dithioacetals 2 are readily prepared from acetylaceton or malononitrile, carbon disulfide, and methyl iodide.
Synthesis of some new spiro(pyran-4,2'-benzoxazole) derivatives
El-Shafei,El-Saghier,Ahmed
, p. 152 - 154 (1994)
Ketene S,S-acetal 2 reacts with 2-aminophenol to afford 2-(1-acetyl-2- oxopropylidene)benzoxazole (3) which was allowed to react with a variety of active methylenes having an α-cyano or α-keto group to give spiro[pyran- 4,2'-benzoxazole] derivatives 5-12. Compound 3 also reacts with bromomalononitrile to afford spiro[3,3-diacetyl-2,2-dicyanocyclopropane- 1,2'-benzoxazole] 13 through a nucleophilic addition and cyclization.
Vilsmeier-Haack reaction of α-oxo ketene dithioacetals to α-chlorovinyl/ethynyl ketene dithioacetals
Dong, Dewen,Liu, Yingchun,Zhao, Yulong,Qi, Yimei,Wang, Zhuo,Liu, Qun
, p. 85 - 91 (2005)
A range of α-oxo ketene dithioacetals 1 reacted with Vilsmeier reagent (POCl3/DMF) to afford a-chlorovinyl ketene dithioacetals 2, With the treatment of NaOH in ethanol or methanol, the compounds 2 were transformed into the corresponding α-ethynyl ketene dithioacetals 3 in moderate to high yields.
EZH2 covalent irreversible inhibitor as well as preparation method and application thereof
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Paragraph 0315; 0317-0319, (2021/08/14)
The invention discloses an EZH2 covalent irreversible inhibitor as well as a preparation method and application thereof. The EZH2 covalent irreversible inhibitor comprises a compound with a structure as shown in a formula (I) or a formula (II) or a salt t
Copper-Catalyzed Annulative Coupling of S,S-Disubstituted Enones with Diazo Compounds to Access Highly Functionalized Thiophene Derivatives
He, Yuan,Lou, Jiang,Wu, Ping,Yu, Zhengkun,Zhou, Yong-Gui
, (2020/01/31)
An efficient protocol toward fully substituted thiophenes and thieno[2,3-b]thiophenes has been developed through CuCl2-catalyzed annulative coupling of S,S-disubstituted enones with diazo compounds under mild conditions. Tetrasubstituted thiophenes and thieno[2,3-b]thiophenes were efficiently accessed by variation of the feed ratio of the reactants in good to excellent yields, respectively. The synthetic methodology has demonstrated the potential for the construction of diverse thiophene derivatives.
Alternative Palladium-Catalyzed Vinylic C?H Difluoroalkylation of Ketene Dithioacetals Using Bromodifluoroacetate Derivatives
Tian, Shuangquan,Song, Xiaoning,Zhu, Dongsheng,Wang, Mang
, p. 1414 - 1419 (2018/04/10)
A palladium-catalyzed cross-coupling of α-oxo ketene dithioacetals and bromodifluoroacetate derivatives has been developed for the synthesis of a class of CF2-containing tetra-substituted olefins, which has potential to extend to drug design an
Palladium-Catalyzed C-S Bond Cleavage with Allenoates: Synthesis of Tetrasubstituted 2-Alkenylfuran Derivatives
Wang, Quannan,Liu, Zhuqing,Lou, Jiang,Yu, Zhengkun
supporting information, p. 6007 - 6011 (2018/10/09)
Palladium-catalyzed C-S cleavage of tetrasubstituted internal alkene α-oxo ketene dithioacetals was realized with allenoates as the coupling partners, efficiently affording tetrasubstituted 2-alkenylfuran derivatives with excellent regioselectivity under mild conditions. Allenoates acted as C1 synthons in the desulfurative [4 + 1] annulation.
In situ generation of PhI+CF3 and transition-metal-free oxidative sp2 C-H trifluoromethylation
Xu, Cong,Liu, Jingxin,Ming, Wenbo,Liu, Yingjie,Liu, Jun,Wang, Mang,Liu, Qun
supporting information, p. 9104 - 9109 (2013/07/26)
These things are sent to tri us: The introduction of CF3 units into organic molecules is important and requires the development of convenient trifluoromethylating reagents. Here, PhI+CF3, an acyclic electrophilic "CF3
Tin tetrachloride-catalyzed regiospecific allylic substitution of quinone monoketals: An easy entry to benzofurans and coumestans
Liu, Yingjie,Liu, Jingxin,Wang, Mang,Liu, Jun,Liu, Qun
supporting information, p. 2678 - 2682 (2013/01/15)
A highly regioselective allylic substitution of quinone monoketals with a-oxoketene dithioacetals is achieved under the catalysis of only tin tetrachloride (1 mol%). The advantages of the reaction, including its simplicity, rapidity, low catalyst loading of inexpensive tin tetrachloride, mild conditions and; in particular, the regiospecificity, is proposed to be due to a pseudo-intramolecular process. This new synthetic method provides a facile [3+2] cycloaddition route to benzofurans and is highlighted by the synthesis of coumestans.
