- Aryliminophosphoranes as Key Intermediates in the One-Pot Synthesis of 1-Aryl-1,3-dihydro-2H-benzimidazol-2-ones from N-Aryl-2-nitrosoanilines and Carbon Dioxide under Mild Metal-Free Conditions
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A new and convenient protocol is presented for the synthesis of 1-arylbenzimidazol-2-ones by a one-pot reaction of N-aryl-2-nitrosoanilines using solid carbon dioxide as a source of the key carbonyl moiety. The metal-free process is carried out under mild conditions and is compatible with a variety of substituents. The atom economy of the synthesis of the starting nitrosoanilines, accomplished by substitution of hydrogen, makes the entire synthesis of the target compounds environmentally friendly.
- ?ukasik, Emilia,Wróbel, Zbigniew
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p. 1159 - 1166
(2016/05/11)
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- Benzimidazole derivatives, their preparation and pharmaceutical use
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A compound having the formula STR1 wherein X is O, SR 4, R 5, R 6 and R 7 independently of each other are hydrogen, halogen, or CF 3 ;R'' is hydrogen or NO 2 ; andfurther a method of treating a disorder or disease of a living animal body, including a huma
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