159117-83-6

Usage

Chemical structure

Benzimidazolone derivative with a trifluoromethyl-substituted phenyl group and a methoxy group

Application

Used in pharmaceutical research and development as a potential drug candidate for the treatment of various diseases and conditions

Mechanism of action

Specific mechanisms are still being explored

Therapeutic potential

Unique chemical structure and properties make it a promising candidate for further study

Safety precautions

Should be handled and used with caution due to its complex structure and potential health hazards

Upstream product

• 146812-90-0 N-(2-amino-4-trifluoromethylphenyl)-2-methoxy-5-trifluoromethylaniline, hydrochloride 
• 463-71-8 thiophosgene 
• 394-25-2 2-methoxy-5-nitrobenzotrifluoride 
• 124-38-9 carbon dioxide 
• 98-46-4 3-trifluoromethylnitrobenzene 
• 349-65-5 2-Methoxy-5-trifluoromethyl-aniline 

Downstream Products

• 153587-01-0 NS 1619 

Relevant academic research and scientific papers

Aryliminophosphoranes as Key Intermediates in the One-Pot Synthesis of 1-Aryl-1,3-dihydro-2H-benzimidazol-2-ones from N-Aryl-2-nitrosoanilines and Carbon Dioxide under Mild Metal-Free Conditions

A new and convenient protocol is presented for the synthesis of 1-arylbenzimidazol-2-ones by a one-pot reaction of N-aryl-2-nitrosoanilines using solid carbon dioxide as a source of the key carbonyl moiety. The metal-free process is carried out under mild conditions and is compatible with a variety of substituents. The atom economy of the synthesis of the starting nitrosoanilines, accomplished by substitution of hydrogen, makes the entire synthesis of the target compounds environmentally friendly.

Benzimidazole derivatives, their preparation and pharmaceutical use

A compound having the formula STR1 wherein X is O, SR 4, R 5, R 6 and R 7 independently of each other are hydrogen, halogen, or CF 3 ;R'' is hydrogen or NO 2 ; andfurther a method of treating a disorder or disease of a living animal body, including a huma