N-Acylglycines: Gas chromatographic mass spectrometric identification and determination in urine by selected ion monitoring
Eleven biologically interesting N-acylglycines have been synthesized and the gas chromatographic and mass spectrometric properties of their trimethylsilyl derivatives studied. A sharp and reproducible gas chromatographic peak could be obtained for each n-acylglycine as the N,O-bis(trimethylsilyl)-N-acylglycine. By the use of these derivatives a sensitive and specific selected ion monitoring method for the determination of N-acylglycines in human urine has been developed.
A pyrone compound represented by formula (1) has an excellent controlling effect on pests. Since the compound of formula (1) has a controlling activity on pests, the compound is useful as an active ingredient of a pest control agent.
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Page/Page column 285
(2011/05/06)
Functionalizing glycine derivatives by direct C-C bond formation
(Chemical Equation Presented) Come on glycine: Two different types of glycine derivatives are α-functionalized using cross-dehydrogenative- coupling (CDC) reactions. The method allows the efficient attachment of a malonate or aromatic alkyne group on the α-position of the glycine derivatives under very mild conditions.
Zhao, Liang,Li, Chao-Jun
supporting information; experimental part
p. 7075 - 7078
(2009/04/07)
Antipsychotic drug
The present invention provides an antipsychotic drug containing essentially an N-acyl amino acid derivative represented by the following general formula:RCO-Awherein R indicates an alkyl or alkenyl having 1-25 carbon atoms, and A is an amino acid residue. The compound is similar to natural products and has little side effect by acting directly to brain cells after passing through easily the blood brain barrier.
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(2008/06/13)
Formation of propionyl-, butyryl-, and other acylglycines by enzymes of Clostridium kluyveri.
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KATZ,LIEBERMAN,BARKER
p. 431 - 441
(2007/10/12)
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