15926-18-8

Usage

Uses

Used in Medical Diagnostics:
N-(2-methyl-1-oxopropyl)-glycine, or N-isobutyrylglycine, is used as a diagnostic tool for the detection and diagnosis of various organic acidemias and mitochondrial fatty acid β-oxidation defects. Its detection is particularly crucial in identifying isobutyryl-CoA dehydrogenase deficiency, a rare genetic disorder that affects the body's ability to process certain fats and proteins.
In the field of medical diagnostics, N-isobutyrylglycine plays a vital role in identifying and monitoring the progression of these conditions, allowing for early intervention and appropriate treatment plans to be implemented.

InChI:InChI=1/C6H11NO3/c1-4(2)6(10)7-3-5(8)9/h4H,3H2,1-2H3,(H,7,10)(H,8,9)

Upstream product

• 79-30-1 isobutyryl chloride 
• 56-40-6 glycine 
• 97-72-3 2-Methylpropionic anhydride 

Downstream Products

• 31766-30-0 ethyl N-isobutyrylglycinate 
• 848150-56-1 (Z)-3-(3,4-dimethoxyphenyl)-2-isobutyrylamino-N-methyl-2-propenamide 

Relevant academic research and scientific papers

N-Acylglycines: Gas chromatographic mass spectrometric identification and determination in urine by selected ion monitoring

Eleven biologically interesting N-acylglycines have been synthesized and the gas chromatographic and mass spectrometric properties of their trimethylsilyl derivatives studied. A sharp and reproducible gas chromatographic peak could be obtained for each n-acylglycine as the N,O-bis(trimethylsilyl)-N-acylglycine. By the use of these derivatives a sensitive and specific selected ion monitoring method for the determination of N-acylglycines in human urine has been developed.

PYRONE COMPOUND AND ITS USE FOR PEST CONTROL

A pyrone compound represented by formula (1) has an excellent controlling effect on pests. Since the compound of formula (1) has a controlling activity on pests, the compound is useful as an active ingredient of a pest control agent.

Functionalizing glycine derivatives by direct C-C bond formation

(Chemical Equation Presented) Come on glycine: Two different types of glycine derivatives are α-functionalized using cross-dehydrogenative- coupling (CDC) reactions. The method allows the efficient attachment of a malonate or aromatic alkyne group on the α-position of the glycine derivatives under very mild conditions.

Antipsychotic drug

The present invention provides an antipsychotic drug containing essentially an N-acyl amino acid derivative represented by the following general formula:RCO-Awherein R indicates an alkyl or alkenyl having 1-25 carbon atoms, and A is an amino acid residue. The compound is similar to natural products and has little side effect by acting directly to brain cells after passing through easily the blood brain barrier.