159326-01-9Relevant articles and documents
Iodine-catalyzed tandem oxidative aromatization for the synthesis of meta-substituted alkoxybenzenes
Jiang, Dahong,Jia, Xicheng,Zhang, Shuhua,Zhang, Zhihua,Li, Lei,Qiao, Yanhui
, (2021/06/12)
A rapid method for the synthesis of meta-substituted alkoxybenzenes is achieved by oxidation of cyclohexenones. This one-pot transformation is catalyzed by molecular iodine with DDQ as an oxidant in the presence of alcohols. Diverse cyclohexenones with aryl or alkyl substitutes are well tolerated to the mild oxidative conditions affording desired products in up to 92% yield. These oxidizing processes were applicable to the efficient synthesis of useful meta-substituted phenolic products which are difficult to obtain by traditional electrophilic substitutions.
Simple and convenient synthesis method of meta-substituted phenol ether and phenol
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Paragraph 0033-0036, (2021/03/11)
The invention relates to the technical field of biological medicines, and provides a preparation method of meta-substituted phenol ether. The method comprises the following steps: taking a derivativeof meta-substituted cyclohexenone as a reaction raw material, reacting under the conditions of an alcohol solvent and an oxidant to obtain corresponding meta-substituted phenol ether; the reaction process is easy to control, the substrate range is wide, and a foundation is laid for providing a simpler and more convenient synthesis method for subsequent preparation of meta-substituted phenol; the invention also provides a simple synthesis method of meta-substituted phenol, and the meta-substituted phenol ether prepared by the method is used as a reaction raw material to solve the problems of need of a noble metal catalyst, high reaction control difficulty and narrow substrate range in the meta-substituted phenol preparation process in the prior art.