Dioxothietanylation of heterocycles 2*. Imidazoles and benzimidazoles
[Figure not available: see fulltext.] 1-(1,1-Dioxidothietan-3-yl)-1H-imidazoles and 1-(1,1-dioxidothietan-3-yl)-1H-benzimidazoles were synthesized in the reaction of 3,5-dibromo-1-(1,1-dioxidothietan-3-yl)-1H-1,2,4-triazole with the sodium salts of imidaz
Makarova, Nadezhda N.,Klen, Elena E.,Khaliullin, Ferkat А.
A novel protecting group for NH functionality of heterocycles, a thietane ring, was proposed. It can be readily introduced by alkylation of NH-heterocycles with 2-chloromethylthiirane. Removal of the thietane protecting group is performed via oxidation to thietane 1,1-dioxide with hydrogen peroxide in acetic acid and subsequent treatment with sodium alkoxide.
Khaliullin,Klen
experimental part
p. 135 - 138
(2009/09/06)
PHARMACOLOGICAL PROPERTIES OF THE PRODUCTS OF THE REACTION OF EPITHIOCHLOROHYDRIN WITH BENZIMIDAZOLES
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Khaliullin, F. A.,Kataev, V. A.,Zaks, A. S.,Terekhova, N. M.,Strokin, Yu. V.
p. 192 - 194
(2007/10/02)
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